Transmembrane Protein 106B (TMEM106B)

TMEM106B expression in frontal cortex. In silico analysis revealed TMEM106B expression in lymphoblastoid cell lines.TMEM106B gene maps to chromosome 7p21.3.For a discussion of a possible association between variation in the TMEM106B gene and susceptibility to frontotemporal lobar degeneration with TDP43 inclusions.

TMEM106B expression compared to controls, and this expression correlated with presence of the T risk allele; these results were found in both GRN-positive and GRN-negative individuals. The results were compatible with a model in which mutations in GRN may act upstream of TMEM106B expression in increasing the risk for FTLD-TDP.