Transmembrane Protein 173 (TMEM173)
NET23; ERIS; MPYS; MITA; STING; Endoplasmic Reticulum Interferon Stimulator; Stimulator Of Interferon Genes Protein; Mediator of IRF3 activation
The deduced 379-amino acid protein has a calculated molecular mass of 42.2 kD. It has 5 putative N-terminal transmembrane domains, a signal cleavage site in the first transmembrane domain, and a leucine-rich region that overlaps the first 4 transmembrane domains. Northern blot analysis detected STING expression in all tissues examined. Confocal microscopy and fractionation analysis of human embryonic kidney 293 cells revealed that STING predominantly associated with the endoplasmic reticulum (ER). Western blot analysis of 293 cells detected endogenous STING at an apparent molecular mass of 42 kD.STING activated both the NF-kappa-B and IRF3 transcription pathways to induce expression of IFN-alpha (IFNA1) and IFN-beta and exert a potent antiviral effect.
Organism species: Homo sapiens (Human)
- Recombinant protein RPN011Hu01 Recombinant Transmembrane Protein 173 (TMEM173) In Stock
- Polyclonal antibody PAN011Hu01 Polyclonal Antibody to Transmembrane Protein 173 (TMEM173) In Stock
- Labelled antibody LAN011Hu81 FITC-Linked Polyclonal Antibody to Transmembrane Protein 173 (TMEM173) In Stock
- Sandwich ELISA SEN011Hu ELISA Kit for Transmembrane Protein 173 (TMEM173) In Stock
- High-sensitive ELISA HEN011Hu High Sensitive ELISA Kit for Transmembrane Protein 173 (TMEM173) In Stock
Organism species: Mus musculus (Mouse)
- Recombinant protein RPN011Mu01 Recombinant Transmembrane Protein 173 (TMEM173) In Stock
- Polyclonal antibody PAN011Mu01 Polyclonal Antibody to Transmembrane Protein 173 (TMEM173) In Stock
- Customized Service n/a CLIA Kit for Transmembrane Protein 173 (TMEM173) CLIA Kit Customized Service Offer
- Customized Service n/a ELISA Kit for Transmembrane Protein 173 (TMEM173) ELISA Kit Customized Service Offer
Organism species: Rattus norvegicus (Rat)
- Recombinant protein RPN011Ra01 Recombinant Transmembrane Protein 173 (TMEM173) In Stock
- Polyclonal antibody PAN011Ra01 Polyclonal Antibody to Transmembrane Protein 173 (TMEM173) In Stock
- Customized Service n/a CLIA Kit for Transmembrane Protein 173 (TMEM173) CLIA Kit Customized Service Offer
- Customized Service n/a ELISA Kit for Transmembrane Protein 173 (TMEM173) ELISA Kit Customized Service Offer