Triadin (TRDN)

Triadin, also known as TRDN, associated with the release of Calcium ions from the sarcoplasmic reticulum triggering muscular contraction through calcium-induced calcium release.

Triadin, a protein found in rabbit triadic junctions, is intrinsic to the terminal cisternae and is closely associated with the RYR1. The predicted 729-amino acid human protein shares 95% identity with rabbit triadin. Like the rabbit protein, human triadin contains a small cytoplasmic domain and a single transmembrane domain. Human triadin has a calculated pI of 9.3 and molecular mass of 82 kD. However, on Western blots, its apparent molecular mass is 117 kD.