Tripartite Motif Containing Protein 37 (TRIM37)

MUL; POB1; TEF3; RING-B-Box-Coiled-Coil Protein; Mulibrey nanism protein; E3 ubiquitin-protein ligase TRIM37

Tripartite Motif Containing Protein 37 (TRIM37)
TRIM37 encodes a member of the tripartite motif (TRIM) family, whose members are involved in diverse cellular functions such as developmental patterning and oncogenesis. The RING finger and B-box domains chelate zinc and might be involved in protein-protein and/or protein-nucleic acid interactions. The gene mutations are associated with mulibrey (muscle-liver-brain-eye) nanism, an autosomal recessive disorder that involves several tissues of mesodermal origin. Alternatively spliced transcript variants encoding the same protein have been identified.The deduced protein contains 979 amino acids. RT-PCR ELISA detected intermediate expression in brain, liver, testis, and ovary, low expression in heart, lung, skeletal muscle, and kidney, and little to no expression in pancreas and spleen.

Organism species: Homo sapiens (Human)

Organism species: Mus musculus (Mouse)

Organism species: Rattus norvegicus (Rat)