USP6 N-Terminal Like Protein (USP6NL)

RNTRE is a 97- to 100-kD protein that stably associates in vivo and in vitro with EPS8 via the SH3 domain of the latter. In vitro, RNTRE displayed remarkable preference for binding to the SH3 domain of EPS8, compared with 8 other SH3s. A C-terminal truncated mutant of RNTRE was able to confer proliferative advantage and reduced serum requirement to NIH 3T3 fibroblasts, suggesting a role for RNTRE in cell proliferation.

Because the 828-amino acid protein encoded by this cDNA shows homology to the N-terminal region of the TRE oncogene, the authors designated it RNTRE, for 'related to the N terminus of TRE.' RNTRE was shown to be ubiquitously expressed.