UbiA Prenyltransferase Domain Containing Protein 1 (UBIAD1)

TERE1 expression in both superficial and muscle-invasive transitional cell carcinomas of bladder (TCCs) compared with normal human urothelium. Transfection of TERE1 into 2 human TCC cell lines inhibited cellular proliferation by 80 to 90%. In 1 line, TERE1 overexpression caused a change in morphology, with an apparent increase in intercellular contacts

The deduced 338-amino acid protein has a calculated molecular mass of 36.8 kD. TERE1 has 5 putative transmembrane regions, an N-glycosylation site, and several putative phosphorylation sites. Northern blot and PCR analyses showed ubiquitous expression of 1.5- and 3-kb TERE1 transcripts. Immunohistochemical analysis of human urothelium revealed nuclear and cytoplasmic expression of TERE1.