Viral Citrullinated Peptide (VCP)
Citrullinated Protein
Anti-VCP antibodies are helpful in discriminating RA from other chronic arthritides or connective tissue disorders. The level of positivity is positively correlated with the anti-CCP level, suggesting that VCP can be considered a novel substrate to detect anti-citrullinated peptide/protein antibodies (ACPA). The reactivity of RA-specific antibodies with a viral citrullinated antigen raises questions on the role of EBV in the induction of ACPA. The presence of autoantibodies against citrullinated proteins in rheumatoid arthritis patients was first described in the mid-seventies when the biochemical basis of antibody reactivity against keratin and filaggrin was investigated. Subsequent studies demonstrated that autoantibodies from RA patients react with a series of different citrullinated antigens, including fibrinogen, deiminated Epstein-Barr Virus Nuclear Antigen 1 and vimentin, which is a member of the intermediate filament family of proteins.
Organism species: Homo sapiens (Human)
- Customized Service n/a Complete Antigen of Viral Citrullinated Peptide (VCP) Antigenic Transformation Customized Service Offer
- Customized Service n/a Monoclonal Antibody to Viral Citrullinated Peptide (VCP) Monoclonal Antibody Customized Service Offer
- Customized Service n/a Polyclonal Antibody to Viral Citrullinated Peptide (VCP) Polyclonal Antibody Customized Service Offer
- Customized Service n/a CLIA Kit for Viral Citrullinated Peptide (VCP) CLIA Kit Customized Service Offer
- Customized Service n/a ELISA Kit for Viral Citrullinated Peptide (VCP) ELISA Kit Customized Service Offer