Von Hippel Lindau Tumor Suppressor (vHL)
HRCA1; RCA1; VHL1; Von Hippel-Lindau Syndrome
The Von Hippel–Lindau tumor suppressor protein is encoded by the VHL gene and when inactivated is associated with Von Hippel–Lindau disease.
The protein encoded by this gene is a component of the protein complex that includes elongin B, elongin C, and cullin-2, and possesses ubiquitin ligase E3 activity. This complex is involved in the ubiquitination and degradation of a hypoxia-inducible-factor (HIF), which is a transcription factor that plays a central role in the regulation of gene expression by oxygen. RNA polymerase II subunit POLR2G/RPB7 is also reported to be a target of this protein. Alternatively spliced transcript variants encoding distinct isoforms have been observed.
Organism species: Homo sapiens (Human)
- Recombinant protein RPJ769Hu01 Recombinant Von Hippel Lindau Tumor Suppressor (vHL) In Stock
- Customized Service n/a Monoclonal Antibody to Von Hippel Lindau Tumor Suppressor (vHL) Monoclonal Antibody Customized Service Offer
- Customized Service n/a Polyclonal Antibody to Von Hippel Lindau Tumor Suppressor (vHL) Polyclonal Antibody Customized Service Offer
- Customized Service n/a CLIA Kit for Von Hippel Lindau Tumor Suppressor (vHL) CLIA Kit Customized Service Offer
- Customized Service n/a ELISA Kit for Von Hippel Lindau Tumor Suppressor (vHL) ELISA Kit Customized Service Offer
Organism species: Mus musculus (Mouse)
- Customized Service n/a Recombinant Von Hippel Lindau Tumor Suppressor (vHL) Recombinant Protein Customized Service Offer
- Customized Service n/a Monoclonal Antibody to Von Hippel Lindau Tumor Suppressor (vHL) Monoclonal Antibody Customized Service Offer
- Customized Service n/a Polyclonal Antibody to Von Hippel Lindau Tumor Suppressor (vHL) Polyclonal Antibody Customized Service Offer
- Customized Service n/a CLIA Kit for Von Hippel Lindau Tumor Suppressor (vHL) CLIA Kit Customized Service Offer
- Customized Service n/a ELISA Kit for Von Hippel Lindau Tumor Suppressor (vHL) ELISA Kit Customized Service Offer
Organism species: Rattus norvegicus (Rat)
- Recombinant protein RPJ769Ra01 Recombinant Von Hippel Lindau Tumor Suppressor (vHL) In Stock
- Monoclonal antibody MAJ769Ra21 Monoclonal Antibody to Von Hippel Lindau Tumor Suppressor (vHL) In Stock
- Polyclonal antibody PAJ769Ra01 Polyclonal Antibody to Von Hippel Lindau Tumor Suppressor (vHL) In Stock
- Monoclonal antibody MAJ769Ra22 Monoclonal Antibody to Von Hippel Lindau Tumor Suppressor (vHL) In Stock
- Sandwich ELISA SEJ769Ra ELISA Kit for Von Hippel Lindau Tumor Suppressor (vHL) In Stock