Wingless Type MMTV Integration Site Family, Member 10A (WNT10A)

WNT10A is a member of the WNT gene family. It is strongly expressed in the cell lines of promyelocytic leukemia and Burkitt's lymphoma. In addition, it and another family member, the WNT6 gene, are strongly coexpressed in colorectal cancer cell lines. The gene overexpression may play key roles in carcinogenesis through activation of the WNT-beta-catenin-TCF signaling pathway. This gene and the WNT6 gene are clustered in the chromosome 2q35 region.

WNT10A encodes a deduced 417-amino acid peptide containing residues conserved among WNTs and 2 N-linked glycosylation sites. WNT10A shares 59.2% amino acid sequence identity with human WNT10B.like WNT1 and WNT10B, WNT10A and WNT6 may play key roles in human carcinogenesis.