Zinc Finger, DHHC-Type Containing Protein 14 (ZDHHC14)

ZDHHC14 belongs to the DHHC palmitoyltransferase family. ERF2/ZDHHC9 subfamily. ZDHHC14 is on 6q25.3, a region gained in pN+ cases of TSCCs compared with pN− cases. Quantitative real-time reverse-transcription polymerase chain reaction showed that ZDHHC14 was overexpressed in all TSCC-derived cell lines compared with primary cultured NOKs at the mRNA level. Similar to the TSCC-derived cell lines, high frequencies of ZDHHC14 up-regulation were evident in mRNA levels of primary tumors.

ZDHHC14 expression may be correlated with lymph node metastasis and offers clues to the planning of new treatments such as early detection, prevention, and therapy for TSCC metastasis.