Zinc Finger Protein 132 (ZNF132)

Transcriptional regulatory proteins containing tandemly repeated zinc finger domains are thought to be involved in both normal and abnormal cellular proliferation and differentiation. One abundant class of such transcriptional regulators resembles the Drosophila Kruppel segmentation gene product due to the presence of repeated Cys2-His2 (C2H2) zinc finger domains that are connected by conserved sequences, called H/C links.

Tommerup et al. (1993) isolated cDNAs potentially encoding zinc finger proteins. Tommerup and Vissing performed sequence analysis on a number of these cDNAs and identified several novel zinc finger protein genes, including ZNF132. The ZNF132 cDNA predicts a 589-amino acid Kruppel-type zinc finger protein that lacks a KRAB domain.