Zinc Finger Protein 205 (ZNF205)

The largest family of zinc finger proteins is the C2H2, or Kruppel, type. Some members of the Kruppel family contain a conserved KRAB region that can be divided into 2 subregions, the A box and the B box.

While constructing a transcript map of the critical region of familial Mediterranean fever, Deng et al. (1998) isolated cDNAs encoding ZNF205, which they designated ZNF210. Sequence analysis indicated that the predicted 504-amino acid protein is a Kruppel-type zinc finger protein that contains a KRAB A box N-terminal to 8 zinc finger motifs. Northern blot analysis revealed that the 2.2-kb ZNF210 mRNA was expressed in all tissues tested. An additional transcript was detected in a number of tissues.