Zinc Finger Protein 22 (ZNF22)

Bray et al. (1991) screened a placental genomic library at moderate stringency with a degenerate oligodeoxynucleotide probe designed to hybridize to the his/cys (H/C) link region between adjoining zinc fingers. Genomic clones were cross-hybridized with a set of 30 zinc finger-encoding cDNAs (KOX1-KOX30) isolated from a human T-cell cDNA library. KOX15 matched one of the genomic clones and was mapped to 10q11 by chromosomal in situ suppression hybridization with fluorescent probe detection. Rousseau-Merck et al. (1992) confirmed the assignment to 10q11.2 and showed that it is distal to ZNF25. A zinc finger protein is a DNA-binding protein domain consisting of zinc fingers ranging from two in the Drosophila regulator ADR1, the more common three in mammalian Sp1 up to nine in TF_IIIA.