Zinc Finger Protein 236 (ZNF236)

ZNF236 expression was upregulated by high, pathologic concentrations of D-glucose. The ZNF236A cDNA encodes a predicted 1,558-amino acid full-length protein containing 25 C2H2 zinc finger motifs. The ZNF236B cDNA encodes a predicted 1,845-amino acid full-length protein containing 30 C2H2 zinc finger motifs.

The zinc fingers are distributed throughout ZNF236A and ZNF236B in clusters of 5 to 9 fingers. Within the clusters, the majority of zinc fingers are connected by a conserved stretch of 7 amino acids, called the H/C link, that is characteristic of the Drosophila repressor protein Kruppel and Kruppel-related zinc finger proteins. An N-terminal Kruppel-associated box (KRAB) is not present in the ZNF236 proteins.