Zinc Finger Protein 263 (ZNF263)

Zinc finger proteins (ZNFs), which bind nucleic acids, perform many key functions, the most important of which is regulating transcription.

The deduced 683-amino acid protein contains 9 C-terminal C2H2-type zinc finger domains, some of which are connected by H/C links; a KRAB A box, which has been shown in other ZNFs to act as a transcriptional repressor domain; and an N-terminal leucine-rich region (LeR) that is also rich in glutamic acids, is highly conserved in a subset of ZNFs, and is predicted to contain 2 alpha helices. Northern blot analysis detected 2 major transcripts of approximately 3.4 and 3.8 kb. ZNF263 was expressed in all human fetal and adult tissues examined.