Zinc Finger Protein 331 (ZNF331)

RITA; ZNF463; ZNF361; C2H2-like zinc finger protein rearranged in thyroid adenomas

Zinc Finger Protein 331 (ZNF331)
Zinc finger proteins have been shown to interact with nucleic acids and to have diverse functions. The zinc finger domain is a conserved amino acid sequence motif containing 2 specifically positioned cysteines and 2 histidines that are involved in coordinating zinc. Kruppel-related proteins form one family of zinc finger proteins. See ZFP93 for additional information on zinc finger proteins.
ZNF463, encoding a 463-amino acid protein with an N-terminal KRAB domain and 12 C-terminal C2H2 zinc finger units. Northern blot analysis revealed testis-restricted expression of a 1.9-kb ZNF463 transcript. RT-PCR analysis demonstrated higher expression of ZNF463 in normal fertile adults than in fetuses or patients with azoospermia, suggesting that ZNF463 may play a role in spermatogenesis.

Organism species: Homo sapiens (Human)