Zinc Finger Protein 354C (ZNF354C)

KID3; Kidney, ischemia, and developmentally-regulated protein 3

Zinc Finger Protein 354C (ZNF354C)
Kid3 encodes a C2H2 zinc finger protein with an N-terminal KRAB transcriptional repression domain. It maps to chromosome 11, adjacent to Kid1 and another related gene Kid2. Northern analysis shows that Kid3 is highly expressed in embryonic and adult brain, with lower levels in adult and embryonic (E16.5) kidney, gut, lung and heart. Expression of Kid3 in the kidney is developmentally regulated and suggests a role for Kid3 in the early stages of nephrogenesis.
AJ18/Kid3/Znf354c are rat, mouse, and human orthologues,respectively, of a protein comprising a Kru¨ ppel-associated box (KRAB) domain and 11 successive C2H2 zinc finger motifs. Rat AJ18 was identified by a differential display screen of foetal rat calvarial cells (FRCCs) as a gene that is up-regulated during osteoblastic differentiation.

Organism species: Homo sapiens (Human)

Organism species: Mus musculus (Mouse)

Organism species: Rattus norvegicus (Rat)