Zinc Finger Protein 627 (ZNF627)

Zinc Finger Protein 627 (ZNF627)
By PCR of genomic DNA using primers based on a sequence encoding a zinc finger motif, followed by screening a human brain cDNA library, Sun et al. (1998) cloned ZNF627. Yamada et al. (2008) stated that the ZNF627 protein contains 11 C2H2-type zinc fingers and a Kruppel-associated box (KRAB) domain.
A zinc finger protein is a DNA-binding protein domain consisting of zinc fingers ranging from two in the Drosophila regulator ADR1, the more common three in mammalian Sp1 up to nine in TFIIIA. They occur in nature as the part of transcription factors conferring DNA sequence specificity as the DNA-binding domain.They have also found use in protein engineering due to their modularity and have prospects as components of tools for use in therapeutic gene modulation and zinc finger nucleases.

Organism species: Homo sapiens (Human)

Organism species: Mus musculus (Mouse)