Zinc Finger Protein 628 (ZNF628)

Znf628, called ZEC (zinc finger expressed in embryonal cells and certain adult organs), from the mouse ICR embryonic brain cDNA library. The deduced 1,038-amino acid protein, which has a calculated molecular mass of 114 kD, contains 18 C2H2-type zinc fingers, which are organized into 2 clusters, and many proline-rich regions. Northern blot analysis showed that Znf628 is strongly expressed in mouse testis, liver, and kidney and in D3 embryonic stem cells and F9 embryonal carcinoma cells. Subcellular localization experiments demonstrated that Znf628 is restricted to the nucleus.

The mouse Znf628 protein specifically binds a potentially novel DNA target sequence and can transactivate a reporter gene driven by this sequence.