Active Heparanase (HPSE) Homo sapiens (Human) Active protein

HPA; HPR1; HPSE1; HSE1; Endo-glucoronidase;

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Overview
Properties
  • Buffer Formulation20mM Tris, 150mM NaCl, pH8.0, containing 1mM EDTA, 1mM DTT, 0.01% SKL, 5% Trehalose and Proclin300.
  • Traits Freeze-dried powder, Purity > 97%
  • Isoelectric Pointn/a
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  • Active Heparanase (HPSE) Packages (Simulation)
  • Active Heparanase (HPSE) Packages (Simulation)
  • APA711Hu01.png Figure. SDS-PAGE
  • Active Heparanase (HPSE) WB Image
  • Certificate ISO9001: 2008, ISO13485: 2003 Registered

Activity test

Usage

Reconstitute in PBS or others.

Storage

Avoid repeated freeze/thaw cycles. Store at 2-8°C for one month. Aliquot and store at -80°C for 12 months.

Stability

The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.

Citations

  • PG545, a Heparan Sulfate Mimetic, Reduces Heparanase Expression In Vivo, Blocks Spontaneous Metastases and Enhances Overall Survival in the 4T1 Breast Carcinoma ModelPlosone: Source
  • Assessment of heparanase and heparin-binding growth and angiogenesis factors in the uterine cavity ? uid in women with impaired reproductionNowinylekarskie:Source
  • Unfractionated heparin attenuates intestinal injury in mouse model of sepsis by inhibiting heparanasePubMed: 26191183
  • PI-88 inhibits postoperative recurrence of hepatocellular carcinoma via disrupting the surge of heparanase after liver resectionPubMed: 26415733
  • Assessment of heparanase and heparin-binding growth and angiogenesis factors in the uterine cavity fluid in women with impaired reproductionarticle:84
  • Plasma heparanase is associated with blood glucose levels but not urinary microalbumin excretion in type 2 diabetic nephropathy at the early stage pubmed:28994624

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