Active Interleukin 4 (IL4) Homo sapiens (Human) Active protein

BSF1; BCGF1 ;B Cell Stimulatory Factor 1; Lymphocyte stimulatory factor 1; B Cell Growth Factor; Binetrakin; Pitrakinra

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Overview
Properties
  • Buffer Formulation20mM Tris, 150mM NaCl, pH8.0, containing 1mM EDTA, 1mM DTT, 0.01% SKL, 5% Trehalose and Proclin300.
  • Traits Freeze-dried powder, Purity > 95%
  • Isoelectric Point9.3
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  • Active Interleukin 4 (IL4) Packages (Simulation)
  • Active Interleukin 4 (IL4) Packages (Simulation)
  • Active Interleukin 4 (IL4) Gene sequencing
  • APA077Hu01.jpg SDS-PAGE
  • Active Interleukin 4 (IL4) Figure. Western Blot; Sample: Recombinant IL4, Human.
  • Certificate ISO9001: 2008, ISO13485: 2003 Registered

Activity test

As reported, IL-4 will induce the differentiation of THP-1 cells into dendritic cells and macrophages in vitro. THP-1 cells were cultured in RPMI-1640 and stimulated with 2ng/mL IL-4, after 10 days of stimulation, partial cells became larger, grew synapses, and had vesicular bodies intracellular, which showed a morphological characteristics of dendritic cells and macrophages.

Usage

Reconstitute in 20mM Tris, 150mM NaCl (PH8.0) to a concentration of 0.1-1.0 mg/mL. Do not vortex.

Storage

Avoid repeated freeze/thaw cycles. Store at 2-8°C for one month. Aliquot and store at -80°C for 12 months.

Stability

The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.

Citations

  • Validation of guinea pig model of allergic rhinitis by oral and topical drugs(guinea pig )PubMed: 18625276
  • Characterization of Anti-Inflammatory Properties and Evidence for No Sedation Liability for the Novel Antihistamine SUN-1334HPubMed: 19672097
  • Dexamethasone attenuates development of monocrotaline-induced pulmonary arterial hypertensionSpringerLink: 76255j50271l4nh2
  • Inflammation influence on the formation of endothelial dysfunction in hypertensive patients caused by obesityKnmu: Source
  • Evaluation of serum concentrations of interleukin (IL)-4, IL-10, and IL-12 during pregnancy in bitchesScienceDirect: S0093691X1300037X
  • Immune Responses to Eimeria tenella Sporozoite Protein as Vaccine to Broiler Against CoccidiosisPjbs: Source
  • Protective effects of neferine on amiodarone-induced pulmonary fibrosis in micePubmed: 23792144
  • Increased blood-circulating interferon-γ, interleukin-17, and osteopontin levels in bovine paratuberculosisPubmed:24679935
  • The toxic effect of nickel nanoparticles on oxidative stress and inflammatory markers.Articles:
  • Roles of lipoxin A4 receptor activation and anti-interleukin-1β antibody on the toll-like receptor 2/mycloid differentiation factor 88/nuclear factor-κB pathway in airway inflammation induced by ovalbuminPubMed: 25760938
  • Evaluation of proliferation and cytokines production by mitogen-stimulated bovine peripheral blood mononuclear cellsArticle_14936_6.Html:
  • Mesenchymal stromal cell-dependent reprogramming of Kupffer cells is mediated by TNF-α and PGE3 and is crucial for liver transplant tolerancePubMed: 25982496
  • The immunomodulating effect of seminal plasma on T cellsPubMed: 25799173
  • Analysis of cytokine production in a newly developed canine tracheal epithelial cell line infected with H3N2 canine influenza virusPubMed: 25797195
  • ЦитокCgi-Bin: Irbis_Nbuv
  • Immune responses of pigs immunized with a recombinant porcine reproductive and respiratory syndrome virus expressing porcine GM-CSFPubMed: 26300317
  • Rescue and evaluation of a recombinant PRRSV expressing porcine Interleukin-4PubMed: 26573719
  • Downregulation of SUMF2 gene in ovalbumin-induced rat model of allergic inflammationPubMed: 26722390
  • Infection of chicken bone marrow mononuclear cells with subgroup J avian leukosis virus inhibits dendritic cell differentiation and alters cytokine expressionPubmed:27349993
  • Immunopotentiators Improve the Efficacy of Oil-Emulsion-Inactivated Avian Influenza Vaccine in Chickens, Ducks and GeesePubmed:27232188
  • Targeted inhibition of GATA-6 attenuates airway inflammation and remodeling by reCavia (Guinea pig )lating caveolin-1 through TLR2/MyD88/NF-ŚĘB in murine model of asthmaPubmed:27289030
  • Proinflammatory and Anti-Inflammatory Cytokines Mediated by NF-ÎşB Factor as Prognostic Markers in Mammary TumorsPubmed:26989335
  • INFLUENCE OF ZINCOVIT DROP (NUTRITIONAL FOOD SUPPLEMENT) ON IMMUNE SYSTEM IN NORMAL AND CYCLOPHOSPHAMIDE INTOXICATED WISTAR RATSjournals:3790
  • Effects of Dectin-1 on the mast cells in allergic conjunctivitis and its underlying mechanismfiles:ijcep0019305.pdf
  • Lymphocytic, cytokine and transcriptomic profiles in peripheral blood of dogs with atopic dermatitispubmed:27553600
  • Recombinant Mip-PilE-FlaA dominant epitopes vaccine candidate against Legionella pneumophila.pubmed:28366526
  • Evaluation of two strains of Marek's disease virus serotype 1 for the development of recombinant vaccines against very virulent infectious bursal disease virus.pubmed:27908832
  • Efficacy of an autophagy-targeted DNA vaccine against avian leukosis virus subgroup J.pubmed:28049588
  • Anti-inflammatory effects of Boletus edulis polysaccharide on asthma pathologypubmed:27830033
  • Targeted inhibition of GATA-6 attenuates airway inflammation and remodeling by regulating caveolin-1 through TLR2/MyD88/NF-κB in murine model of asthmapubmed:27289030
  • EVALUATION OF HUMORAL AND CELLULAR IMMUNE RESPONSES TO EIMERIA TENELLA OOCYST PROTEIN AS VACCINE TO BROILER363-379.pdf
  • Proinflammatory and Anti-Inflammatory Cytokines Mediated by NF-κB Factor as PrognosticMarkers in Mammary Tumors.pubmed:26989335
  • Characterization of Simian Immunodeficiency Virus Variants Anatomically Compartmentalized inPlasma and Milk in Chronically Infected African Green Monkeys.pubmed:
  • Long-term use of ceftriaxone sodium induced changes in gut microbiota and immune system.pubmed:28220870
  • Imbalance of intestinal immune function in piglets infected by porcine circovirus type 2 during the fetal period.pubmed:28244338
  • Oral administration of Clostridium butyricum CGMCC0313‐1 reduces ovalbumin‐induced allergic airway inflammation in micepubmed:28250847
  • Cytokine levels in colostrum and in foals' serum pre- and post-sucklingpubmed:28242000
  • Effect of boron on thymic cytokine expression, hormone secretion, antioxidant functions, cell proliferation, and apoptosis potential via the ERK1/2 signaling pathwaypubmed:29032684
  • COMPARATIVE EFFICACY OF TWO HETEROLOGOUS CAPRIPOX VACCINES TO CONTROL LUMPY SKIN DISEASE IN CATTLEISSN 1311-1477
  • The effect of feed supplementation with effective microorganisms(EM) on pro- and anti-inflammatory cytokine concentrations in pigspubmed:28549299
  • Anti-asthmatic efect of pitavastatin through aerosol inhalation is associated with CD4+ CD25+ Foxp3+ T cells in an asthma mouse modelpubmed:28729731
  • The effects of Spirulina platensis (Arthrospira platensis) and Saccharomyces cerevisiae on the distribution and cytokine production of CD4+ and CD8+ T …S0719-81322017000300185
  • Evaluation of Cell-mediated Immune Response in PBMCs of Calves Vaccinated by Capri Pox Vaccines Using ELISA and Real-time RT-PCRDOI: 10.18869/acadpub.rmm.5.2.3
  • Stress Induced Polarization of Immune-Neuroendocrine Phenotypes in Gallus galluspubmed:28808318
  • Single dose of consensus hemagglutinin-based virus-like particles vaccine protects chickens against divergent H5 subtype influenza virusespubmed:29230222
  • Antigen-Sparing and Enhanced Efficacy of Multivalent Vaccines Adjuvanted with Immunopotentiators in Chickenspubmed:28603519
  • Oral administration of Clostridium butyricum CGMCC0313-1 reduces ovalbumin-induced allergic airway inflammation in micepubmed:28122397
  • Administration of probiotic mixture DM#1 ameliorated 5-fluorouracil-induced intestinal mucositis and dysbiosis in ratspubmed:27427511
  • Milk and serum IL-4, IL-6, IL-10, and amyloid A concentrations in cows with subclinical mastitis caused by coagulase-negative staphylococcipubmed:28964518
  • EGCG Maintains Th1/Th2 Balance and Mitigates Ulcerative Colitis Induced by Dextran Sulfate Sodium through TLR4/MyD88/NF-ݜ傠Signaling Pathway in Rats10.1155/2017/3057268
  • The immune impact of mimic endoscopic retrograde appendicitis therapy and appendectomy on rabbits of acute appendicitis.pubmed:29029533
  • Optimization of Storage Temperature for Retention of Undifferentiated Cell Character of Cultured Human Epidermal Cell Sheetspubmed:28811665
  • A study of altered cytokine rhythms associated with successful implantation in cows10.1080/09291016.2017.1361159
  • Sex differences in complex regional pain syndrome type I (CRPS-I) in micepubmed:28831269
  • EGCG Maintains Th1/Th2 Balance and Mitigates Ulcerative Colitis Induced by Dextran Sulfate Sodium through TLR4/MyD88/NF-κB Signaling Pathway in Rats10.1155/2017/3057268
  • Systemic and Tumor Th1 and Th2 Inflammatory Profile and Macrophages in Lung Cancer: Influence of Underlying Chronic Respiratory Disease.pubmed:27793775
  • Commensal bacteria aggravate allergic asthma via NLRP3/IL-1β signaling in post-weaning mice10.1016:j.jaut.2018.07.003
  • A Novel Role of Irbesartan in Gastroprotection against Indomethacin-Induced Gastric Injury in Rats: Targeting DDAH/ADMA and EGFR/ERK SignalingPubmed:29523851
  • Selenium deficiency inhibits differentiation and immune function and imbalances the Th1/Th2 of dendritic cellsPubmed:29766201
  • A flagellin-adjuvanted PED subunit vaccine improved protective efficiency against PEDV variant challenge in pigsPubmed:29891346
  • Immunogenicity and protective efficacy of recombinant fiber-2 protein in protecting SPF chickens against fowl adenovirus 4Pubmed:29395523
  • Chitosan oligosaccharide ameliorates acute lung injury induced by blast injury through the DDAH1/ADMA pathwayPubmed:29415054
  • Epstein Barr Virus Infection Affects Function of Cytotoxic T Lymphocytes in Patients with Severe Aplastic AnemiaPubmed:29862282
  • Effect of Multi-Microbial Probiotic Formulation Bokashi on Pro-and Anti-Inflammatory Cytokines Profile in the Serum, Colostrum and Milk of Sows, and in a …Pubmed:29305686
  • Involvement of T-Helper 9 Activation in a Mouse Model of Allergic RhinitisPubmed:29982264
  • Analysis of the immune response of calves to various saponin-based adjuvants for an experimental vaccinePubmed:29958518
  • Construction of Pullorum ghost by co-expression of lysis gene E and the antimicrobial peptide SMAP29 and evaluation of its immune efficacy in specific …10.1016:S2095-3119(17)61696-4
  • Changes in Th1/Th2-producing cytokines during acute exacerbation chronic obstructive pulmonary diseasePubmed:29950127
  • Immune response characteristics of Capri pox virus vaccines following emergency vaccination of cattle against lumpy skin disease virus65381
  • خصوصیات پاسخ‌های ایمنی القاء شده ناشی از واکسن زنده تخفیف حدت یافته آبله بزی سویه گرگان بر علیه بیماری لمپی اسکین در گاو‎
  • Natural killer T cell ligand alpha-galactosylceramide protects against gut ischemia reperfusion-induced organ injury in micePubmed: 30195979
  • Intradermal injection of Pythium insidiosum protein antigens for improved diagnosis and treatment of pythiosis in an experimental modelPubmed: 30260397
  • Anti-asthmatic activity of alkaloid compounds from Pericarpium Citri Reticulatae (Citrus reticulata 'Chachi')Pubmed: 19363516
  • ANP/NPRA Inhibits Epithelial-Mesenchymal Transition of Airway by Targeting Smad3 in Asthma
  • Protective effects of polydatin in free and nanocapsulated form on changes caused by lipopolysaccharide in hippocampal organotypic cultures
  • Metabolomics analysis of baicalin on ovalbumin-sensitized allergic rhinitis rats
  • Construction and Immunogenicity of Novel Chimeric Virus-Like Particles Bearing Antigens of Infectious Bronchitis Virus and Newcastle Disease VirusPubmed: 30871190
  • Neuroinflammation induced by lipopolysaccharide causes cognitive impairment in micePubmed: 30962497
  • Local probiotic Lactobacillus crispatus and Lactobacillus delbrueckii exhibit strong antifungal effects against vulvovaginal candidiasis in a rat model
  • Preclinical study of safety and immunogenicity of combined rubella and human papillomavirus vaccines: Towards enhancing vaccination uptake rates in …Pubmed: 31185296
  • Antibacterial immunomodulatory and antibiofilm triple effect of Salivaricin LHM against Pseudomonas aeruginosa urinary tract infection modelPubmed: 31136751
  • Co-Expression of Chicken IL-2 and IL-7 Enhances the Immunogenicity and Protective Efficacy of a VP2-Expressing DNA Vaccine against IBDV in ChickensPubmed: 31137731
  • CD28 deficiency attenuates primary blast-induced renal injury in mice via the PI3K/Akt signalling pathwayPubmed: 31129646
  • Atmospheric H2S triggers immune damage by activating the TLR-7/MyD88/NF-κB pathway and NLRP3 inflammasome in broiler thymus
  • MODULATION OF LIPOPOLYSACCHARIDE-INDUCED CYTOKINES RESPONSE IN MICE BY GRAVIOLA LEAF POWDER
  • Protective effect of Vitamin D3 against lead induced hepatotoxicity, oxidative stress, immunosuppressive and calcium homeostasis disorders in rat
  • Anti-Inflammatory State in Arabian Horses Introduced to the Endurance TrainingPubmed: 31462005
  • CD4+ CD25+ Tregs as dependent factor in the course of bleomycin-induced pulmonary fibrosis in micePubmed: 31678213
  • Qingkailing injection ameliorates cerebral ischemia-reperfusion injury and modulates the AMPK/NLRP3 Inflammasome Signalling pathwayPubmed: 31747940
  • Melatonin biosynthesis restored by CpG oligodeoxynucleotides attenuates allergic airway inflammation via regulating NLRP3 inflammasomePubmed: 31738882
  • The therapeutic effect of dendritic cells expressing indoleamine 2, 3-dioxygenase (IDO) on an IgA nephropathy mouse modelPubmed: 31894556
  • Rotundic Acid Protects against Metabolic Disturbance and Improves Gut Microbiota in Type 2 Diabetes RatsPubmed: 31887996
  • Suppression of Fpr2 expression protects against endotoxin-induced acute lung injury by interacting with Nrf2-regulated TAK1 activationPubmed: 32106380
  • Effects of Early Intervention with Antibiotics and Maternal Fecal Microbiota on Transcriptomic Profiling Ileal Mucusa in Neonatal PigsPubmed: 31963653
  • TLR2-Melatonin Feedback Loop Regulates the Activation of NLRP3 Inflammasome in Murine Allergic Airway InflammationPubmed: 32117301
  • Inhibitory effects of catalpol coordinated with budesonide and their relationship with cytokines and Interleukin-13 expressionPubmed: 31737193
  • Tectorigenin inhibits inflammation and pulmonary fibrosis in allergic asthma model of ovalbumin‐sensitized guinea pigsPubmed: 32314371
  • Ectopic expression of 35 kDa and knocking down of 78 kDa SG2NAs induce cytoskeletal reorganization, alter membrane sialylation, and modulate the markers of EMTPubmed: 33083950
  • Chlorogenic acid prevents acute myocardial infarction in rats by reducing inflammatory damage and oxidative stressPubmed: 33022535
  • Effect of procyanidins on lipid metabolism and inflammation in rats exposed to alcohol and ironPubmed: 32964156
  • Construction of polycistronic baculovirus surface display vectors to express the PCV2 Cap (d41) protein and analysis of its immunogenicity in mice and swinePubmed: 32907618
  • Porcine soluble CD83 alleviates LPS-induced abortion in mice by promoting Th2 cytokine production, Treg cell generation and trophoblast invasionPubmed: 32810792
  • Active smoking, sleep quality and cerebrospinal fluid biomarkers of neuroinflammationPubmed: 32717405
  • Fasciola gigantica excretory-secretory products (FgESPs) modulate the differentiation and immune functions of buffalo dendritic cells through a mechanism …Pubmed: 32680553
  • Integrated metabolomics and gut microbiome to the effects and mechanisms of naoxintong capsule on type 2 diabetes in ratsPubmed: 32616735
  • Lactobacillus rhamnosus 2016SWU.05.0601 regulates immune balance in ovalbumin‐sensitized mice by modulating the immune‐related transcription factors …Pubmed: 32478427
  • Protective effect of Asarum sieboldii essential oil on ovalbumin induced allergic rhinitis in ratPubmed: 32395767
  • USP8 protects against lipopolysaccharide-induced cognitive and motor deficits by modulating microglia phenotypes through TLR4/MyD88/NF-κB signaling pathway in …Pubmed: 32335193
  • M10, a Myricetin-3-ObD-Lactose Sodium Salt, Prevents Ulcerative Colitis Through Inhibiting Necroptosis in MicePubmed: 33041798
  • Qingfei oral liquid alleviates airway hyperresponsiveness and mucus hypersecretion via TRPV1 signaling in RSV-infected asthmatic micePubmed: 32521453
  • Mahuang Xixin Fuzi Decoction protects against ovalbumin-induced allergic rhinitis by inhibiting type 2 innate lymphoid cells in mice
  • 鸡骨髓源树突状细胞体外诱导
  • Evaluation of lipopolysaccharide-induced acute lung injury attenuation in mice by Glycyrrhiza glabra
  • Tissue-Engineered Decellularized Allografts for Anterior Cruciate Ligament Reconstruction
  • Experimental autoimmune encephalomyelitis inhibited by Huangqi Guizhi Wuwu Decoction by enhancing Th2 cytokine
  • Immunogenicity and protective efficacy of enterotoxigenic Escherichia coli (ETEC) total RNA against ETEC challenge in a mouse model33239756
  • Effect of alfalfa hay and starter feed supplementation on caecal microbiota and fermentation, growth, and health of yak calves33610512
  • Qingfei oral liquid inhibited autophagy to alleviate inflammation via mTOR signaling pathway in RSV-infected asthmatic mice33706133
  • Asiatic acid attenuates diabetic retinopathy through TLR4/MyD88/NF-¦ÊB p65 mediated modulation of microglia polarization33965378
  • Beneficial impact of cathelicidin on hypersensitivity pneumonitis treatment¡ªIn vivo studies33999928
  • Melatonin ameliorates anxiety-like behaviors induced by sleep deprivation in mice: role of oxidative stress, neuroinflammation, autophagy and apoptosis34144202
  • Construction and Immunogenicity Comparison of Three Virus-Like Particles Carrying Different Combinations of Structural Proteins of Avian Coronavirus Infectious?¡­33670249
  • The Effect of the Clenbuterol¡ª¦Â2-Adrenergic Receptor Agonist on the Peripheral Blood Mononuclear Cells Proliferation, Phenotype, Functions, and Reactive Oxygen?¡­33920705
  • Experimental autoimmune encephalomyelitis inhibited by Huangqi Guizhi Wuwu Decoction via Th2 cytokine enhancement
  • Talaromyces marneffei and nontuberculous mycobacteria co-infection in HIV-negative patients34376749
  • Inhibition of NF-κB/IL-33/ST2 Axis Ameliorates Acute Bronchiolitis Induced by Respiratory Syncytial Virus34395633
  • Allicin ameliorates renal ischemia/reperfusion injury via inhibition of oxidative stress and inflammation in rats34426252
  • Cytokine profile in serum and gingival crevicular fluid of children with inflammatory bowel disease: A case‐control study34730850
  • Associations between expression of indoleamine 2, 3-dioxygenase enzyme and inflammatory cytokines in patients with first-episode drug-naive …34802039
  • Dexmedetomidine exerts cerebral protective effects against cerebral ischemic injury by promoting the polarization of M2 microglia via the Nrf2/HO-1/NLRP3 pathway34767031
  • Optimizing the growth and immune system of dairy calves by subdividing the pre-weaning period and providing different milk volumes for each stage34786502
  • Clenbuterol, a Selective β2-Adrenergic Receptor Agonist, Inhibits or Limits Post-Stroke Pneumonia, but Increases Infarct Volume in MCAO MicePubmed:35058704
  • The microRNA-1278/SHP-1/STAT3 pathway is involved in airway smooth muscle cell proliferation in a model of severe asthma both intracellularly and extracellularlyPubmed:35157180
  • Protection from Benzene-induced Immune Dysfunction in MicePubmed:35090963
  • Jiangu granule ameliorated OVX rats bone loss by modulating gut microbiota-SCFAs-Treg/Th17 axisPubmed:35453007
  • Photobiomodulation associated with lipid nanoparticles and hyaluronic acid accelerate the healing of excisional woundsPubmed:35705485
  • Synergistic Pathogenicity by Coinfection and Sequential Infection with NADC30-like PRRSV and PCV2 in Post-Weaned PigsPubmed:35215787
  • Dexmedetomidine Attenuates Hyperalgesia Induced By Brachial Plexus Root Avulsion By Restoring The GLT-1 Function Via PKA Signaling
  • Th1/Th2 cytokine polarization in milk according to different pathogens causing subclinical mastitis in cows

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