Monoclonal Antibody to Cross Linked C-Telopeptide Of Type I Collagen (CTXI) Homo sapiens (Human) Monoclonal antibody

CTX-I; CTX1;

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Overview
Properties
  • SourceMonoclonal antibody preparation, Host Mouse
  • Ig Isotype N/A, Clone Number C8
  • PurificationProtein A + Protein G affinity chromatography
  • LabelNone
  • Immunogen n/a
  • Buffer Formulation0.01M PBS, pH7.4, containing 0.05% Proclin-300, 50% glycerol.
  • TraitsLiquid, Concentration 1mg/ml
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  • Monoclonal Antibody to Cross Linked C-Telopeptide Of Type I Collagen (CTXI) Packages (Simulation)
  • Monoclonal Antibody to Cross Linked C-Telopeptide Of Type I Collagen (CTXI) Packages (Simulation)
  • Monoclonal Antibody to Cross Linked C-Telopeptide Of Type I Collagen (CTXI) DAB staining on IHC-P; Sample: Human Liver Tissue; Primary Ab: 20µg/ml Mouse Anti-Multi-species CTXI Antibody Second Ab: 2µg/mL HRP-Linked Caprine Anti-Mouse IgG Polyclonal Antibody (Catalog: SAA544Mu19)
  • Monoclonal Antibody to Cross Linked C-Telopeptide Of Type I Collagen (CTXI) DAB staining on IHC-P;
    Sample: Human Liver cancer Tissue;
    Primary Ab: 20µg/ml Mouse Anti-Multi-species CTXI Antibody
    Second Ab: 2µg/mL HRP-Linked Caprine Anti-Mouse IgG Polyclonal Antibody
    (Catalog: SAA544Mu19)
  • Monoclonal Antibody to Cross Linked C-Telopeptide Of Type I Collagen (CTXI) DAB staining on IHC-P;
    Sample: Human Stomach Tissue;
    Primary Ab: 20µg/ml Mouse Anti-Multi-species CTXI Antibody
    Second Ab: 2µg/mL HRP-Linked Caprine Anti-Mouse IgG Polyclonal Antibody
    (Catalog: SAA544Mu19)
  • Monoclonal Antibody to Cross Linked C-Telopeptide Of Type I Collagen (CTXI) DAB staining on IHC-P;
    Sample: Human Stomach cancer Tissue;
    Primary Ab: 20µg/ml Mouse Anti-Multi-species CTXI Antibody
    Second Ab: 2µg/mL HRP-Linked Caprine Anti-Mouse IgG Polyclonal Antibody
    (Catalog: SAA544Mu19)
  • Certificate ISO9001: 2008, ISO13485: 2003 Registered

Specifity

The antibody is a mouse monoclonal antibody raised against CTXI. It has been selected for its ability to recognize CTXI in immunohistochemical staining and western blotting.

Usage

Western blotting: 0.5-2µg/mL;
Immunohistochemistry: 5-20µg/mL;
Immunocytochemistry: 5-20µg/mL;
Optimal working dilutions must be determined by end user.

Storage

Store at 4°C for frequent use. Stored at -20°C in a manual defrost freezer for two year without detectable loss of activity. Avoid repeated freeze-thaw cycles.

Stability

The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.

Giveaways

Citations

  • Atp6v0d2 Is an Essential Component of the Osteoclast-Specific Proton Pump That Mediates Extracellular Acidification in Bone ResorptionPubMed: PMC2672205
  • Borage and fish oils lifelong supplementation decreases inflammation and improves bone health in a murine model of senile osteoporosisPubMed: 21664309
  • Is there benefit in optimising heart failure treatment in over-80 year-old patients? (HF-80 study): study protocol for a randomized controlled trial.Trials: 1745-6215
  • TRAF family member-associated NF-κB activator (TANK) is a negative regulator of osteoclastogenesis and bone formationPubMed: 22773835
  • A Mediterranean Diet Enriched with Olive Oil Is Associated with Higher Serum Total Osteocalcin Levels in Elderly Men at High Cardiovascular RiskPubMed: PMC3462931
  • Oxytocin Reverses Ovariectomy-Induced Osteopenia and Body Fat GainEndocrine: Source
  • DPP IV inhibitor treatment attenuates bone loss and improves mechanical bone strength in male diabetic ratsPubmed:25053403
  • Relation of burden of myocardial fibrosis to malignant ventricular arrhythmias and outcomes in Fabry diseasePubmed:25073565
  • Bone resorption correlates with the frequency of CD5+ B cells in the blood of patients with rheumatoid arthritisPubmed:25193807
  • XPO1/CRM1-Selective Inhibitors of Nuclear Export (SINE) reduce tumor spreading and improve overall survival in preclinical models of prostate cancer (PCa)Pubmed:25284315
  • The presence of FCGR2B promoter or transmembrane region variant alleles leads to reduced serum IL-6 levels in rheumatoid arthritisPubmed:25630523
  • 5-azacytidine-induced protein 2 (AZI2) regulates bone mass by fine-tuning osteoclast survivalPubmed:25691576
  • Osteocartilaginous metabolic markers change over a 3-week stage race in pro-cyclistsPubMed: 26174975
  • Effects of renal tubular dysfunction on bone in tenofovir-exposed HIV-positive patientsPubMed: 26372384
  • Biomarkers in Remission According to Different Criteria in Patients with Rheumatoid ArthritisPubMed: 26472417
  • Curcumin alleviates glucocorticoid-induced osteoporosis through the regulation of the Wnt signaling pathwayPubMed: 26677102
  • Mutation in Osteoactivin Promotes RANKL-Mediated Osteoclast Differentiation and Survival, but Inhibits Osteoclast FunctionPubMed: 25837253
  • Oxytocin reverses osteoporosis in a sex-dependent mannerPubMed: 26042090
  • The RIP1–RIP3 Complex Mediates Osteocyte Necroptosis after Ovariectomy in Ratspmc:PMC4795547
  • Lanthanum Chloride Attenuates Osteoclast Formation and Function Via the DownreCavia (Guinea pig )lation of Rankl-Induced Nf-κb and Nfatc1 ActivitiesPubmed:26060084
  • N-Homocysteinylation impairs collagen cross-linking in cystathionine β-synthase-deficient mice: a novel mechanism of connective tissue abnormalities.pubmed:27530978
  • High FGF21 levels are associated with altered bone homeostasis in HIV-1-infected patients.pubmed:28521869
  • The effect of calcium and vitamin D supplementation on bone health of male Jockeys.pubmed:27568072
  • Ginsenosides Rg3 attenuates glucocorticoid-induced osteoporosis through regulating BMP-2/BMPR1A/Runx2 signaling pathwaypubmed:27387537
  • The effect of lamotrigine and phenytoin on bone turnover and bone strength: A prospective study in Wistar ratspubmed:27838501
  • Reduced femoral bone mass in both diet-induced and genetic hyperlipidemia micepubmed:27669658
  • A potential role for glycated cross-links in abdominal aortic aneurysm disease.pubmed:27624703
  • Effects of long-term administration of pantoprazole on bone mineral density in young male rats.pubmed:27552060
  • Anti-osteoporotic effects of an antidepressant tianeptine on ovariectomized ratsS0753332216322752
  • Cannabidiol administration reduces sublesional cancellous bone loss in rats with severe spinal cord injurypubmed:28479140
  • Side-Effects of Convulsive Seizures and Anti-Seizure Therapy on Bone in a Rat Model of Epilepsypubmed:28905646
  • Obesity status influences the relationship among serum osteocalcin, iron stores and insulin sensitivitypubmed:29050649
  • A novel osteoporosis model with ascorbic acid deficiency in Akr1A1 gene knockout mice.pubmed:28060768
  • 骨形成指标PINP 与骨吸收指标β-CTX 在2 型糖尿病合并骨质疏松中作用的研究.10.3969/j.issn.1006-7108.2017.03.009
  • Optimization of the Time Window of Interest in Ovariectomized Imprinting Control Region Mice for Antiosteoporosis Researchpubmed:29119115
  • TSC1 regulates osteoclast podosome organization and bone resorption through mTORC1 and Rac1/Cdc42Pubmed:29358671
  • The role of androgens on periodontal repair in female ratsPubmed:29683499
  • Myricetin ameliorates glucocorticoid-induced osteoporosis through the ERK signaling pathwayPubmed:29883721
  • The effect of levetiracetam on rat bone mineral density, bone structure and biochemical markers of bone metabolismPubmed:29428468
  • Geometric and mechanical bone response to a multidisciplinary weight loss intervention in adolescents with obesity: The ADIBOX studyPubmed:30076009
  • Effects of Amlodipine on Bone Metabolism in Orchidectomised Spontaneously Hypertensive RatsPubmed:29898457
  • Liraglutide exerts a bone‑protective effect in ovariectomized rats with streptozotocin‑induced diabetes by inhibiting osteoclastogenesisPubmed:29805533
  • Combination therapy with BMP‑2 and psoralen enhances fracture healing in ovariectomized mice10.3892:etm.2018.6353
  • Dual PI3 K/mTOR inhibition reduces prostate cancer bone engraftment altering tumor-induced bone remodelingPubmed:29687745
  • Membrane-Based Microwave-Mediated Electrochemical Immunoassay for the In Vitro, Highly Sensitive Detection of Osteoporosis-Related BiomarkersPubmed: 30181433
  • Mollugin attenuates glucocorticoid-induced osteoporosis in rats via Akt/P13K pathway
  • Transcriptome analysis of osteoblasts in an ovariectomized mouse model in response to physical exercise
  • Influence of physical training on markers of bone turnover, mechanical properties, morphological alterations, density and mineral contents in the femur of rats exposed …Pubmed: 30983556
  • Serum biomarkers for predicting overall survival and early mortality in older patients with metastatic solid tumorsPubmed: 30952517
  • Significance of the Tks4 scaffold protein in bone tissue homeostasis
  • E The Effects of Ficus Carica Fruit on Bone Markers and Oestrogen Level of Post-Menopausal Osteoporotic Rats
  • Osteocyte TSC1 promotes sclerostin secretion to restrain osteogenesis in micePubmed: 31088250
  • Role of testosterone and androgen receptor in periodontal disease progression in female ratsPubmed: 31389012
  • Biomarkers of oral inflammation in perinatally HIV‐infected and perinatally HIV exposed, uninfected youthPubmed: 31385616
  • Laboratory Monitoring of Bone Tissue Remodeling after Augmentation of Impression Intraarticular Fracture with Different Types of Bone GraftPubmed: 31630302
  • AAV-anti-miR-214 prevents collapse of the femoral head in osteonecrosis by regulating osteoblast and osteoclast activitiesPubmed: 31739209
  • Alleviating Effect of α-Lipoic Acid and Magnesium on Cadmium-Induced Inflammatory Processes, Oxidative Stress and Bone Metabolism Disorders in Wistar RatsPubmed: 31739465
  • Differences in Osteoimmunological Biomarkers Predictive of Psoriatic Arthritis among a Large Italian Cohort of Psoriatic PatientsPubmed: 31717649
  • Beneficial effects of Cuscuta chinensis extract on glucocorticoid-induced osteoporosis through modulation of RANKL/OPG signalsPubmed: 31826180
  • BMP9 reduces bone loss in ovariectomized mice by dual regulation of bone remodelingPubmed: 31914211
  • EDTA-Modified 17β-Estradiol-Laden Upconversion Nanocomposite for Bone-Targeted Hormone Replacement Therapy for OsteoporosisPubmed: 32194868
  • Article Dual CXCR4 and E-Selectin Inhibitor, GMI-1359, Shows Anti-Bone Metastatic Effects and Synergizes with Docetaxel in Prostate Cancer Cell Intraosseous …Pubmed: 31877673
  • RNA Sensing by Gut Piezo1 Is Essential for Systemic Serotonin SynthesisPubmed: 32640190
  • A Loop‐Based and AGO‐Incorporated Virtual Screening Model Targeting AGO‐Mediated miRNA–mRNA Interactions for Drug Discovery to Rescue Bone Phenotype …Pubmed: 32670749
  • The Effects of Ficus Carica Fruit on Bone Markers and Oestrogen Level of Post-Menopausal Osteoporotic Rats.
  • Dual CXCR4 and E-Selectin Inhibitor, GMI-1359, Shows Anti-Bone Metastatic Effects and Synergizes with Docetaxel in Prostate Cancer Cell Intraosseous …
  • Qu Feng Zhi Tong capsule increases mechanical properties of cortical bone in ovariectomized rats
  • 4-Hexylresorcinol Inhibits Osteoclastogenesis by Suppressing NF‐κB Signaling Pathway and Reverses Bone Loss in Ovariectomized Mice
  • The Effects of Ficus Carica Fruit on Bone Markers and Oestrogen Level of Post-Menopausal Osteoporotic Rats
  • 淫羊藿水提物及提取药渣的抗骨质疏松药效比较研究
  • Postmenapozal Tip-2 diyabetes mellitus' lu hastalarda osteoporoza bağlı kırık riskinin ve kemik Turnoveri'nin değerlendirilmesi
  • A biomimetically hierarchical polyetherketoneketone scaffold for osteoporotic bone repair33310848
  • Lgr4 promotes aerobic glycolysis and differentiation in osteoblasts via the canonical Wnt/¦Â©\catenin pathway33950533
  • Andrographolide prevents bone loss via targeting ERRalpha‐regulated metabolic adaption of osteoclastogenesis34233019
  • Effects of icariin on the fracture healing in young and old rats and its mechanism34511043
  • Gujiansan Ameliorates Avascular Necrosis of the Femoral Head by Regulating Autophagy via the HIF-1α/BNIP3 Pathway34512780
  • Dual integrin αvβ3 and αvβ5 blockade attenuates cardiac dysfunction by reducing fibrosis in a rat model of doxorubicin-induced cardiomyopathy34296634
  • Night shift work and osteoporosis-bone turnover markers among female blue-collar workers in PolandPubmed:35139709
  • Defects in a liver-bone axis contribute to hepatic osteodystrophy disease progressionPubmed:35235775
  • BMP9 reduces age-related bone loss in mice by inhibiting osteoblast senescence through Smad1-Stat1-P21 axisPubmed:35523787
  • Foxf2 represses bone formation via Wnt2b/β-catenin signalingPubmed:35668101
  • Osteoporotic bone recovery by a bamboo-structured bioceramic with controlled release of hydroxyapatite nanoparticlesPubmed:35386445
  • Puerarin specifically disrupts osteoclast activation via blocking integrin-β3 Pyk2/Src/Cbl signaling pathwayPubmed:35228997
  • Exercised accelerated the production of muscle-derived kynurenic acid in skeletal muscle and alleviated the postmenopausal osteoporosis through the Gpr35 …

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