Monoclonal Antibody to Thrombin/Antithrombin Complex (TAT) Homo sapiens (Human) Monoclonal antibody

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Overview
Properties
  • SourceMonoclonal antibody preparation, Host Mouse
  • Ig Isotype IgG, Clone Number n/a
  • PurificationAntigen-specific affinity chromatography followed by Protein A affinity chromatography
  • LabelNone
  • Immunogen n/a
  • Buffer FormulationPBS, pH7.4, containing 0.02% NaN3, 50% glycerol.
  • TraitsLiquid, Concentration 1mg/mL
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  • Monoclonal Antibody to Thrombin/Antithrombin Complex (TAT) Packages (Simulation)
  • Monoclonal Antibody to Thrombin/Antithrombin Complex (TAT) Packages (Simulation)
  • Monoclonal Antibody to Thrombin/Antithrombin Complex (TAT) AF488 staining on IF;
    Sample: HepG2 cell
    Primary Ab: 30µg/ml Mouse Anti-Human TAT Antibody
    Second Ab: 2μg/ml AF488-Linked Caprine Anti-Mouse IgG Polyclonal Antibody
    (Catalog: SAA544Mu11)
  • Certificate ISO9001: 2008, ISO13485: 2003 Registered

Specifity

The antibody is a mouse monoclonal antibody raised against TAT. It has been selected for its ability to recognize TAT in immunohistochemical staining and western blotting.

Usage

Western blotting: 0.2-2µg/mL;1:500-5000
Immunohistochemistry: 5-20µg/mL;1:50-200
Immunocytochemistry: 5-20µg/mL;1:50-200
Optimal working dilutions must be determined by end user.

Storage

Store at 4°C for frequent use. Stored at -20°C in a manual defrost freezer for two year without detectable loss of activity. Avoid repeated freeze-thaw cycles.

Stability

The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.

Giveaways

Citations

  • Genetic repression of mouse VEGF expression regulates coagulation cascade.PubMed: 21086498
  • Treatment with unfractionated heparin attenuates coagulation and inflammation in endotoxemic miceScienceDirect: S0049384811004166
  • High sCD40L levels early after trauma are associated with enhanced shock, sympathoadrenal activation, tissue and endothelial damage, coagulopathy and mortalityWiley: source
  • Tissue factor and PAR1 promote microbiota-induced intestinal vascular remodellingNature: 20120329
  • Prolonged Exposure to Sphingosine 1–Phosphate Receptor-1 Agonists Exacerbates Vascular Leak, Fibrosis, and Mortality after Lung InjuryPubMed: PMC2993087
  • Host Defense Peptides of Thrombin Modulate Inflammation and Coagulation in Endotoxin-Mediated Shock and Pseudomonas aeruginosa SepsisPubMed: PMC3521733
  • Clinical impact of factor V Leiden, prothrombin G20210A, and MTHFR C677T mutations among sickle cell disease patients of Central IndiaPubmed: 23992124
  • Selected hemostatic parameters in patients with pancreatic tumors.Pubmed:Pmc4297344
  • TFPI1 Mediates Resistance to Doxorubicin in Breast Cancer Cells by Inducing a Hypoxic-Like ResponsePubmed:24489651
  • Novel evidence that crosstalk between the complement, coagulation and fibrinolysis proteolytic cascades is involved in mobilization of hematopoietic stem/progenitor cells (HSPCs)Pubmed:24667943
  • Thrombomodulin Improved Liver Injury, Coagulopathy, and Mortality in an Experimental Heatstroke Model in MicePubmed:24781566
  • Evidence of a Pivotal Role for the Distal Part of the Complement Cascade in the Diurnal Release of Hematopoietic Stem Cells Into Peripheral BloodPubmed:26087465
  • (S)YS-51, a novel isoquinoline alkaloid, attenuates obesity-associated non-alcoholic fatty liver disease in mice by suppressing lipogenesis, inflammation and coaCavia (Guinea pig )lationPubmed:27343380
  • Coagulation factor XI vaccination: an alternative strategy to prevent thrombosis.pubmed:27813324
  • Nebulized Heparin Attenuates Pulmonary Coagulopathy and Inflammation through Alveolar Macrophages in a Rat Model of Acute Lung Injurypubmed:29202212
  • Platelet-localized FXI promotes a vascular coagulation-inflammatory circuit in arterial hypertensionpubmed:28148841
  • Activated TAFI Promotes the Development of Chronic Thromboembolic Pulmonary Hypertension: A Possible Novel Therapeutic Targetpubmed:28289017
  • Nebulized anti-coagulants as a therapy for acute lung injury and acute respiratory distress syndromePubmed: 29202212
  • The circadian rhythm of selected parameters of the hemostasis system in healthy people
  • Transduced Tat-aldose Reductase Protects Hippocampal Neuronal Cells against Oxidative Stress-induced DamagePubmed: 31698553
  • The impact of dabigatran treatment on sinusoidal protection against hepatic ischemia‐reperfusion injury in micePubmed: 33108682
  • Doxorubicin contributes to thrombus formation and vascular injury via enhancing platelet functions in vivoPubmed: 32469636
  • Preservation of renal endothelial integrity and reduction of renal edema by aprotinin does not preserve renal perfusion and function following experimental …34169407
  • Complement factor D is linked to platelet activation in human and rodent sepsis34396466

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