Alcoholic Hepatitis (AH)

Alcoholic hepatitis, alcoholic liver disease is inflammation of the liver due to excessive intake of alcohol. It is usually found in association with fatty liver, an early stage of alcoholic liver disease, and may contribute to the progression of fibrosis, leading to cirrhosis. Signs and symptoms of alcoholic hepatitis include jaundice, ascites, fatigue and hepatic encephalopathy. Mild cases are self-limiting, but severe cases have a high risk of death. Severe cases may be treated with glucocorticoids. 

Animal models for alcoholic hepatitis contain 'ethanol intragastric feeding model'，'Lieber-Decarli model' and ‘Tsukarnoto-French model'etc.. The use of animal models has contributed to greater understanding of how alcoholic hepatitis develops, and of how the severity of liver injury is influenced by factors other than alcohol, such as nutrition, oxygen deprivation and gene regulation.