Bone Morphogenetic Protein 10 (BMP10)

Bone morphogenetic protein 10 (BMP10) is a polypeptide belonging to the TGF-beta superfamily of proteins.It is a novel protein that, unlike most other BMP's, is likely to be involved in the tabeculation of the heart. Bone morphogenetic proteins are known for their ability to induce bone and cartilage development. BMP10 is categorized as a BMP since it shares a large sequence homology with other BMP's in the TGF-beta superfamily.

Required for maintaining the proliferative activity of embryonic cardiomyocytes by preventing premature activation of the negative cell cycle regulator CDKN1C/p57KIP and maintaining the required expression levels of cardiogenic factors such as MEF2C and NKX2-5. Inhibits endothelial cell migration and growth.