11-Beta-Hydroxysteroid Dehydrogenase Type 1 (HSD11b1)
11DH; 11-beta-HSD1; HDL; HSD11; HSD11B; HSD11L; SDR26C1; Corticosteroid 11-beta-dehydrogenase isozyme 1; Short Chain Dehydrogenase/Reductase Family 26C,Member 1
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11b-hydroxysteroid dehydrogenase type 1 is an NADPH-dependent enzyme highly expressed in key metabolic tissues including liver, adipose tissue, and the central nervous system. In these tissues, HSD11B1 reduces cortisone to the active hormone cortisol that activates glucocorticoid receptors. It is inhibited by carbenoxolone, a drug typically used in the treatment of peptic ulcers. The protein encoded by this gene is a microsomal enzyme that catalyzes the conversion of the stress hormone cortisol to the inactive metabolite cortisone. In addition, the encoded protein can catalyze the reverse reaction, the conversion of cortisone to cortisol. Too much cortisol can lead to central obesity, and a particular variation in this gene has been associated with obesity and insulin resistance in children.
Organism species: Homo sapiens (Human)
- Recombinant protein RPC268Hu01 Recombinant 11-Beta-Hydroxysteroid Dehydrogenase Type 1 (HSD11b1) In Stock
- Polyclonal antibody PAC268Hu01 Polyclonal Antibody to 11-Beta-Hydroxysteroid Dehydrogenase Type 1 (HSD11b1) In Stock
- Monoclonal antibody MAC268Hu22 Monoclonal Antibody to 11-Beta-Hydroxysteroid Dehydrogenase Type 1 (HSD11b1) In Stock
- Sandwich ELISA SEC268Hu ELISA Kit for 11-Beta-Hydroxysteroid Dehydrogenase Type 1 (HSD11b1) In Stock
Organism species: Mus musculus (Mouse)
- Recombinant protein RPC268Mu01 Recombinant 11-Beta-Hydroxysteroid Dehydrogenase Type 1 (HSD11b1) In Stock
- Polyclonal antibody PAC268Mu01 Polyclonal Antibody to 11-Beta-Hydroxysteroid Dehydrogenase Type 1 (HSD11b1) In Stock
- Sandwich ELISA SEC268Mu ELISA Kit for 11-Beta-Hydroxysteroid Dehydrogenase Type 1 (HSD11b1) In Stock
Organism species: Rattus norvegicus (Rat)
- Recombinant protein RPC268Ra01 Recombinant 11-Beta-Hydroxysteroid Dehydrogenase Type 1 (HSD11b1) In Stock
- Polyclonal antibody PAC268Ra01 Polyclonal Antibody to 11-Beta-Hydroxysteroid Dehydrogenase Type 1 (HSD11b1) In Stock
- Monoclonal antibody MAC268Ra21 Monoclonal Antibody to 11-Beta-Hydroxysteroid Dehydrogenase Type 1 (HSD11b1) In Stock
- Sandwich ELISA SEC268Ra ELISA Kit for 11-Beta-Hydroxysteroid Dehydrogenase Type 1 (HSD11b1) In Stock