Insulin Degrading Enzyme (IDE)
Insulysin; Insulin Protease; Abeta-degrading protease; Insulinase
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Insulin Degrading Enzyme (IDE) is a large zinc-binding protease of the M16A metalloprotease subfamily known to cleave multiple short polypeptides that vary considerably in sequence. IDE was first identified by its ability to degrade the B chain of the hormone insulin. This activity was observed over fifty years ago, though the enzyme specifically responsible for B chain cleavage was identified more recently. This discovery revealed considerable amino acid sequence homology between IDE and the previously characterized bacterial protease pitrilysin, suggesting a common proteolytic mechanism. IDE, which migrates at 110 kDa during gel electrophoresis under denaturing conditions, has since been shown to have additional substrates, including the signaling peptides glucagon, TGF alpha, and beta-endorphin.
Organism species: Homo sapiens (Human)
- Recombinant protein RPB897Hu01 Recombinant Insulin Degrading Enzyme (IDE) In Stock
- Active protein APB897Hu01 Active Insulin Degrading Enzyme (IDE) In Stock
- Polyclonal antibody PAB897Hu01 Polyclonal Antibody to Insulin Degrading Enzyme (IDE) In Stock
- Monoclonal antibody MAB897Hu22 Monoclonal Antibody to Insulin Degrading Enzyme (IDE) In Stock
- Monoclonal antibody MAB897Hu21 Monoclonal Antibody to Insulin Degrading Enzyme (IDE) In Stock
- Sandwich ELISA SEB897Hu ELISA Kit for Insulin Degrading Enzyme (IDE) In Stock
Organism species: Mus musculus (Mouse)
- Recombinant protein RPB897Mu01 Recombinant Insulin Degrading Enzyme (IDE) In Stock
- Recombinant protein RPB897Mu02 Recombinant Insulin Degrading Enzyme (IDE) In Stock
- Polyclonal antibody PAB897Mu01 Polyclonal Antibody to Insulin Degrading Enzyme (IDE) In Stock
- Polyclonal antibody PAB897Mu02 Polyclonal Antibody to Insulin Degrading Enzyme (IDE) In Stock
- Sandwich ELISA SEB897Mu ELISA Kit for Insulin Degrading Enzyme (IDE) In Stock
Organism species: Rattus norvegicus (Rat)
- Recombinant protein RPB897Ra01 Recombinant Insulin Degrading Enzyme (IDE) In Stock
- Polyclonal antibody PAB897Ra01 Polyclonal Antibody to Insulin Degrading Enzyme (IDE) In Stock
- Monoclonal antibody MAB897Ra21 Monoclonal Antibody to Insulin Degrading Enzyme (IDE) In Stock
- Sandwich ELISA SEB897Ra ELISA Kit for Insulin Degrading Enzyme (IDE) In Stock