Interleukin 17F (IL17F)

IL-17F has been shown to stimulate prolifertion and activation of T cells and PBMCs, to inhibit angiogenesis as well as to regulate cartilage matrix turnover. This recombinant IL-17F is a homodimeric protein with a total weight of 30.1kDa containing two 134 amino acid residue chains.Using nested RACE PCR with leukocyte-anchored cDNA, Starnes et al. (2001) isolated an IL17F cDNA encoding a 153-amino acid protein that shares 40% homology with IL17.

In addition to the 2 invariant disulfide bonds found in other members of the IL17 family, IL17F contains a signal peptide with an extra cys-cys pair that could function as an extra disulfide bond. Expression of IL17F could not be identified by Northern blot analysis. RT-PCR analysis detected expression in activated, but not resting, CD4+ T cells and activated monocytes.