Mucin 6 (MUC6)

Reid and Harris (1998) used tissue in situ hybridization to study MUC6 gene expression in midtrimester human fetal gut. MUC6 mRNA was detected at low levels in the small intestine between 13 and 23 weeks' gestation. Abundant MUC6 mRNA was detected in gastric neck mucous cells, in contrast with MUC5AC . MUC6 mRNA was present at high levels in pancreatic ductal epithelium throughout the midtrimester.

Rousseau et al. (2004) described the domain structure of human MUC6. MUC6 contains an N-terminal signal peptide, followed by several Von Willebrand factor (VWF)-like domains, a large tandem repeat domain, and a C-terminal cystine knot domain.