Sirtuin 3 (SIRT3)
SIR2L3; Silent Mating Type Information Regulation 2 Homolog 3; NAD-dependent protein deacetylase sirtuin-3, mitochondrial; SIR2-like protein 3; Regulatory protein SIR2 homolog 3
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SIRT3 is a soluble protein located in the mitochondrial matrix, and contains a mitochondrial processing peptide at the N-terminus. A set of crystal structures of human SIRT3 have been solved, including an apo-structure with no substrate, a structure with a peptide containing acetyl lysine of its natural substrate acetyl-CoA synthetase 2, a reaction intermediate structure trapped by a thioacetyl peptide and a structure with the dethioacetylated peptide bound. These structures show the conformational changes induced by the two substrates required for the reaction, the acetylated substrate peptide and NAD+. In addition, a binding study by isothermal titration calorimetry suggests that the acetylated peptide is the first substrate to bind to SIRT3, prior to NAD+.
Organism species: Homo sapiens (Human)
- Recombinant protein RPE913Hu01 Recombinant Sirtuin 3 (SIRT3) In Stock
- Active protein APE913Hu01 Active Sirtuin 3 (SIRT3) In Stock
- Polyclonal antibody PAE913Hu01 Polyclonal Antibody to Sirtuin 3 (SIRT3) In Stock
- Labelled antibody LAE913Hu71 Biotin-Linked Polyclonal Antibody to Sirtuin 3 (SIRT3) In Stock
- Labelled antibody LAE913Hu81 FITC-Linked Polyclonal Antibody to Sirtuin 3 (SIRT3) In Stock
- Monoclonal antibody MAE913Hu21 Monoclonal Antibody to Sirtuin 3 (SIRT3) In Stock
- Monoclonal antibody MAE913Hu22 Monoclonal Antibody to Sirtuin 3 (SIRT3) In Stock
- Monoclonal antibody MAE913Hu23 Monoclonal Antibody to Sirtuin 3 (SIRT3) In Stock
- Labelled antibody LAE913Hu42 PE-Linked Monoclonal Antibody to Sirtuin 3 (SIRT3) In Stock
- Sandwich ELISA SEE913Hu ELISA Kit for Sirtuin 3 (SIRT3) In Stock
Organism species: Mus musculus (Mouse)
- Recombinant protein RPE913Mu01 Recombinant Sirtuin 3 (SIRT3) In Stock
- Recombinant protein RPE913Mu02 Recombinant Sirtuin 3 (SIRT3) In Stock
- Active protein APE913Mu01 Active Sirtuin 3 (SIRT3) In Stock
- Polyclonal antibody PAE913Mu01 Polyclonal Antibody to Sirtuin 3 (SIRT3) In Stock
- Polyclonal antibody PAE913Mu02 Polyclonal Antibody to Sirtuin 3 (SIRT3) In Stock
- Sandwich ELISA SEE913Mu ELISA Kit for Sirtuin 3 (SIRT3) In Stock
Organism species: Rattus norvegicus (Rat)
- Recombinant protein RPE913Ra01 Recombinant Sirtuin 3 (SIRT3) In Stock
- Active protein APE913Ra01 Active Sirtuin 3 (SIRT3) In Stock
- Polyclonal antibody PAE913Ra01 Polyclonal Antibody to Sirtuin 3 (SIRT3) In Stock
- Labelled antibody LAE913Ra71 Biotin-Linked Polyclonal Antibody to Sirtuin 3 (SIRT3) In Stock
- Monoclonal antibody MAE913Ra21 Monoclonal Antibody to Sirtuin 3 (SIRT3) In Stock
- Sandwich ELISA SEE913Ra ELISA Kit for Sirtuin 3 (SIRT3) In Stock