Eukaryotic Kidney Injury Molecule 1 (Kim1) Mus musculus (Mouse) Eukaryotic protein

HAVCR1; TIM1; TIMD1; HAVCR; Hepatitis A Virus Cellular Receptor 1; T Cell Immunoglobulin And Mucin Domain-Containing Protein 1; T-cell immunoglobulin mucin receptor 1

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Overview
Properties
  • Source Eukaryotic expression, Host 293F cell
  • Endotoxin Level<1.0EU per 1µg (determined by the LAL method)
  • Subcellular LocationSecreted
  • Molecular Mass 25.3kDa, Accurate 56kDa(Analysis of differences refer to the manual)
  • Residues & TagsTyr22~Gly237 with N-terminal His Tag
  • Buffer Formulation20mM Tris, 150mM NaCl, pH8.0, containing 1mM EDTA, 1mM DTT, 0.01% SKL, 5% Trehalose and Proclin300.
  • Traits Freeze-dried powder, Purity > 90%
  • Isoelectric Point8.7
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  • Eukaryotic Kidney Injury Molecule 1 (Kim1) Packages (Simulation)
  • Eukaryotic Kidney Injury Molecule 1 (Kim1) Packages (Simulation)
  • Eukaryotic Kidney Injury Molecule 1 (Kim1) Figure . Gene Sequencing (extract)
  • EPA785Mu61.jpg Figure. SDS-PAGE
  • Certificate ISO9001: 2008, ISO13485: 2003 Registered

Sequence

Usage

Reconstitute in 20mM Tris, 150mM NaCl (pH8.0) to a concentration of 0.1-1.0 mg/mL. Do not vortex.

Storage

Avoid repeated freeze/thaw cycles. Store at 2-8°C for one month. Aliquot and store at -80°C for 12 months.

Stability

The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.

Citations

  • Clinical implication of urinary neutrophil gelatinase-associated lipocalin and kidney injury molecule-1 in patients with acute paraquat intoxicationPubMed: 19827907
  • KIM-1 and NGAL: new markers of obstructive nephropathySpringerLink: v461592787w5488x
  • Urinary Neutrophil Gelatinase-Associated Lipocalin at Birth Predicts Early Renal Function in Very Low Birth Weight InfantsLWW: 10000
  • Markers of kidney function in the elderly in relation to the new CKD-EPI formula for estimation of glomerular filtration rateAMS: source
  • Targeting the AGE-RAGE axis improves renal function in the context of a healthy diet low in advanced glycation end-product contentPubMed: 23046363
  • Comprehensive assessment of nephrotoxicity of intravenously administered sodium-oleate-coated ultra-small superparamagnetic iron oxide (USPIO) and titanium dioxide (TiO(2)) nanoparticles in rats.PubMed: 23272807
  • A Mouse Diversity Panel Approach Reveals the Potential for Clinical Kidney Injury Due to DB289 Not Predicted by Classical Rodent ModelsPubMed: PMC3498743
  • Interleukin 18 as a Marker of Chronic Nephropathy in Children after Anticancer TreatmentHindawi: 369784
  • Urinary Measurement of Neutrophil Gelatinase Associated Lipocalin and Kidney Injury Molecule-1 Helps Diagnose Acute Pyelonephritis in a Preclinical ModelHindawi: 413853
  • Kidney injury molecule-1: a urinary biomarker for contrast induced acute kidney injury.Iiste: Source
  • Urinary neutrophil gelatinase-associated lipocalin predicts graft loss after acute kidney injury in kidney transplantPubmed: 24325180
  • Targeting the AGE-RAGE axis improves renal function in the context of a healthy diet low in advanced glycation end-product content.Pubmed: 23046363
  • The Renal Effects of Vanadate Exposure: Potential Biomarkers and Oxidative Stress as a Mechanism of Functional Renal Disorders—Preliminary StudiesHindawi: 740105
  • Attenuation of renal ischemia/reperfusion injury by a?aí extract preconditioning in a rat modelPubmed:25476829
  • Urinary Kim-1 is a sensitive biomarker for the early stage of diabetic nephropathy in Otsuka Long-Evans Tokushima Fatty ratsSagepub:Source
  • 中性粒细胞明胶酶相关脂质运载蛋白、肾损伤分子1和白介素18 在诊断心肺分流术后急性肾损伤中的意义Jcp-Sh:Source
  • Tubular urinary biomarkers do not identify aetiology of acute kidney injury in kidney transplant recipientsPubmed:24666430
  • Cilostazol Renoprotective Effect: Modulation of PPAR-γ, NGAL, KIM-1 and IL-18 Underlies Its Novel Effect in a Model of Ischemia-ReperfusionPubmed:24816434
  • SYNbiotics Easing Renal failure by improving Gut microbiologY (SYNERGY): a protocol of placebo-controlled randomised cross-over trialPubmed:24996842
  • The diagnosis of febrile urinary tract infection in children may be facilitated by urinary biomarkersPubmed:25127917
  • Systemic and Flap Inflammatory Response Associates with Thrombosis in Flap Venous CrisisPubmed:25448261
  • Kidney injury molecule-1: A urinary biomarker for contrast-induced acute kidney injuryTmjournals:Source
  • Rosiglitazone attenuates renal injury caused by hyperlipidemic pancreatitisPubMed: 26191125
  • Inhalation of hydrogen gas ameliorates glyoxylate-induced calcium oxalate deposition and renal oxidative stress in micePubMed: 26045773
  • Vorinostat protects against calcium oxalate-induced kidney injury in micePubMed: 26095064
  • Role of new biomarkers for predicting renal scarring in vesicoureteral reflux: NGAL, KIM-1, and L-FABPPubMed: 26324091
  • Urinary NGAL, KIM-1 and L-FABP concentrations in antenatal hydronephrosisPubMed: 26096437
  • Intrarenal Renin-Angiotensin System Mediates Fatty Acid-Induced ER Stress in the KidneyPubMed: 26672616
  • Attenuation of renal ischemia/reperfusion injury by oleanolic acid preconditioning via its antioxidant, anti‑inflammatory, and anti‑apoptotic activities.Pubmed:27082705
  • Preconditioned suppression of prolyl-hydroxylases attenuates renal injury but increases mortality in septic murine modelsPubmed:26908768
  • Kidney Injury Molecule Levels in Type 2 Diabetes MellitusPubmed:27132791
  • Protective Effect of Dihydromyricetin Against Lipopolysaccharide-Induced Acute Kidney Injury in a Rat Modelpmc:PMC4754091
  • Deficiency in Apoptosis-Inducing Factor Recapitulates Chronic Kidney Disease via Aberrant Mitochondrial HomeostasisPubmed:26822084
  • Once daily administration of the SGLT2 inhibitor, empagliflozin, attenuates markers of renal fibrosis without improving albuminuria in diabetic db/db micePubmed:27226136
  • Vitamins C and E Alleviate Nephrotoxicity-induced by Potassium Bromate in RatsBarakat812016JALSI28698.pdf
  • Synergic Effect of α-Mangostin on the Cytotoxicity of Cisplatin in a Cervical Cancer Model.pubmed:28053694
  • Attenuation of renal ischemia/reperfusion injury by oleanolic acid preconditioning via itsantioxidant, anti‑inflammatory, and anti‑apoptotic activities.pubmed:27082705
  • Protective Effects of DHA-PC against Vancomycin-Induced Nephrotoxicity through the Inhibition of Oxidative Stress and Apoptosis in BALB/c Micepubmed:29254330
  • Early urinary biomarkers of renal tubular damage by a high-salt intake independent of blood pressure in normotensive rats.pubmed:29027259
  • Urinary Kidney Injury Molecule-1 but Not Urinary Neutrophil Gelatinase Associated Lipocalin Is Increased after Short Maximal Exercise10.1159/000481179
  • Gum Acacia Improves Renal Function and Ameliorates Systemic Inflammation, Oxidative and Nitrosative Stress in Streptozotocin-Induced Diabetes in Rats …Pubmed:29550811
  • Exploring the therapeutic mechanism of Desmodium styracifolium on oxalate crystal-induced kidney injuries using comprehensive approaches based on …Pubmed:29950996
  • Effect of Pinocembrin Isolated from Mexican Brown Propolis on Diabetic NephropathyPubmed:29642511
  • Modeling heart failure risk in diabetes and kidney disease: limitations and potential applications of transverse aortic constriction in high-fat-fed micePubmed:29443547
  • Effect of Aqueous Extract of Glycyrrhiza glabra on the Biochemical Changes Induced by Cadmium Chloride in RatsPubmed: 30251228
  • A Phage Display-Identified Peptide Selectively Binds to Kidney Injury Molecule-1(KIM-1) and Detects KIM-1-Overexpressing Tumors in vivo
  • Urinary neutrophil gelatinase-associated lipocalin, kidney injury molecule-1, N-acetyl-β-D-glucosaminidase levels and mortality risk in septic patients with …Pubmed: 30393493
  • UPLC/MS-Based Metabolomics Investigation of the Protective Effect of Hydrogen Gas Inhalation on Mice with Calcium Oxalate-Induced Renal InjuryPubmed: 30381664
  • The Kidney Specific Protein myo-Inositol Oxygenase, a Potential Biomarker for Diabetic NephropathyPubmed: 30504713
  • Urine markers of renal tubular injury in idiopathic membranous nephropathy: A cross sectional studyPubmed: 30684459
  • Dual actions on gout flare and acute kidney injury along with enhanced renal transporter activities by Yokuininto, a Kampo medicinePubmed: 30871515
  • Application of ELISA Technique and Human Microsomes in the Search for 11β-Hydroxysteroid Dehydrogenase InhibitorsDoi: BioMed Research International
  • Piceatannol protects against cisplatin nephrotoxicity via activation of Nrf2/HO-1 pathway and hindering NF-κB inflammatory cascadePubmed: 31197431
  • Effect of Cucumis melo var. flexuosus leaves extract on renal oxidative injury and inflammation in diabetic male albino rats
  • Toxicity assessment due to prenatal and lactational exposure to lead, cadmium and mercury mixturesPubmed: 31639605
  • page Metabolomics study of fasudil on cisplatin-induced kidney injuryPubmed: 31670380
  • MiR-214-3p exacerbates kidney damages and inflammation induced by hyperlipidemic pancreatitis complicated with acute renal injuryPubmed: 31790686
  • Protective effect of saxagliptin against renal ischaemia reperfusion injury in ratsPubmed: 31979992
  • Delineating a role for the Mitochondrial Permeability Transition Pore in Diabetic Kidney Disease by targeting Cyclophilin DPubmed: 31943002
  • Rapamycin improves renal injury induced by Iodixanol in diabetic rats by deactivating the mTOR/p70S6K signaling pathwayPubmed: 32798557
  • Serum NGAL, KIM-1, IL-18, L-FABP: new biomarkers in the diagnostics of acute kidney injury (AKI) following invasive cardiology proceduresPubmed: 32557377
  • Can Serum Neutrophil Gelatinase Associated Lipocalin and Kidney Injury Molecule-1 Help in Decision Making for Surgery in Antenatally Dedected …Pubmed: 33139211
  • Ratlarda sodyum florid ile oluşturulan toksikasyonda Karvakol'ün böbrekler üzerine etkisi
  • Rationale and design of the intervention in PHOspholamban RElated CArdiomyopathy STudy (i-PHORECAST)
  • Early Kidney Injury in Immunoglobulin A Vasculitis: Role of Renal Biomarkers33423326
  • Value of urinary kidney injury molecule-1 levels in predicting acute kidney injury in very low birth weight preterm infants33372811
  • Renal Protective Effect of Beluga Lentil Pretreatment for Ischemia-Reperfusion Injury33604384
  • Targeting Methylglyoxal in Diabetic Kidney Disease Using the Mitochondria-Targeted Compound MitoGamide33922959
  • Kim-1 Targeted Extracellular Vesicles: A New Therapeutic Platform for RNAi to Treat AKI34127536
  • Anti-oxidant impact of Lisinopril and Enalapril against acute kidney injury induced by doxorubicin in male Wistar rats: involvement of kidney injury molecule-133506137
  • Pentoxifylline treatment alleviates kidney ischemia/reperfusion injury: Novel involvement of galectin-3 and ASK-1/JNK & ERK1/2/NF-¦ÊB/HMGB-1 trajectories34030796
  • Could urinary kidney injury molecule-1 be a good marker in subclinical acute kidney injury in mild to moderate COVID-19 infection?34213713
  • Preservation of renal endothelial integrity and reduction of renal edema by aprotinin does not preserve renal perfusion and function following experimental …34169407
  • Kidney disease risk factors do not explain impacts of low dietary protein on kidney function and structure34820603

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