Eukaryotic Thrombin/Antithrombin Complex (TAT) Homo sapiens (Human) Eukaryotic protein

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Overview
Properties
  • Source Eukaryotic expression, Host 293F cell
  • Endotoxin Level<1.0EU per 1µg (determined by the LAL method)
  • Subcellular LocationSecreted
  • Molecular Mass n/a, Accurate n/a(Analysis of differences refer to the manual)
  • Residues & TagsN-terminal His Tag
  • Buffer FormulationPBS, pH7.4, containing 5% Trehalose.
  • Traits Freeze-dried powder, Purity > 95%
  • Isoelectric Pointn/a
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  • Eukaryotic Thrombin/Antithrombin Complex (TAT) Packages (Simulation)
  • Eukaryotic Thrombin/Antithrombin Complex (TAT) Packages (Simulation)
  • EPA831Hu61.png Figure. SDS-PAGE
  • Certificate ISO9001: 2008, ISO13485: 2003 Registered

Sequence

Usage

Reconstitute in PBS or others.

Storage

Avoid repeated freeze/thaw cycles. Store at 2-8°C for one month. Aliquot and store at -80°C for 12 months.

Stability

The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.

Citations

  • Genetic repression of mouse VEGF expression regulates coagulation cascade.PubMed: 21086498
  • Treatment with unfractionated heparin attenuates coagulation and inflammation in endotoxemic miceScienceDirect: S0049384811004166
  • High sCD40L levels early after trauma are associated with enhanced shock, sympathoadrenal activation, tissue and endothelial damage, coagulopathy and mortalityWiley: source
  • Tissue factor and PAR1 promote microbiota-induced intestinal vascular remodellingNature: 20120329
  • Prolonged Exposure to Sphingosine 1–Phosphate Receptor-1 Agonists Exacerbates Vascular Leak, Fibrosis, and Mortality after Lung InjuryPubMed: PMC2993087
  • Host Defense Peptides of Thrombin Modulate Inflammation and Coagulation in Endotoxin-Mediated Shock and Pseudomonas aeruginosa SepsisPubMed: PMC3521733
  • Clinical impact of factor V Leiden, prothrombin G20210A, and MTHFR C677T mutations among sickle cell disease patients of Central IndiaPubmed: 23992124
  • Selected hemostatic parameters in patients with pancreatic tumors.Pubmed:Pmc4297344
  • TFPI1 Mediates Resistance to Doxorubicin in Breast Cancer Cells by Inducing a Hypoxic-Like ResponsePubmed:24489651
  • Novel evidence that crosstalk between the complement, coagulation and fibrinolysis proteolytic cascades is involved in mobilization of hematopoietic stem/progenitor cells (HSPCs)Pubmed:24667943
  • Thrombomodulin Improved Liver Injury, Coagulopathy, and Mortality in an Experimental Heatstroke Model in MicePubmed:24781566
  • Evidence of a Pivotal Role for the Distal Part of the Complement Cascade in the Diurnal Release of Hematopoietic Stem Cells Into Peripheral BloodPubmed:26087465
  • (S)YS-51, a novel isoquinoline alkaloid, attenuates obesity-associated non-alcoholic fatty liver disease in mice by suppressing lipogenesis, inflammation and coaCavia (Guinea pig )lationPubmed:27343380
  • Coagulation factor XI vaccination: an alternative strategy to prevent thrombosis.pubmed:27813324
  • Nebulized Heparin Attenuates Pulmonary Coagulopathy and Inflammation through Alveolar Macrophages in a Rat Model of Acute Lung Injurypubmed:29202212
  • Platelet-localized FXI promotes a vascular coagulation-inflammatory circuit in arterial hypertensionpubmed:28148841
  • Activated TAFI Promotes the Development of Chronic Thromboembolic Pulmonary Hypertension: A Possible Novel Therapeutic Targetpubmed:28289017
  • Nebulized anti-coagulants as a therapy for acute lung injury and acute respiratory distress syndromePubmed: 29202212
  • The circadian rhythm of selected parameters of the hemostasis system in healthy people
  • Transduced Tat-aldose Reductase Protects Hippocampal Neuronal Cells against Oxidative Stress-induced DamagePubmed: 31698553
  • The impact of dabigatran treatment on sinusoidal protection against hepatic ischemia‐reperfusion injury in micePubmed: 33108682
  • Doxorubicin contributes to thrombus formation and vascular injury via enhancing platelet functions in vivoPubmed: 32469636
  • Preservation of renal endothelial integrity and reduction of renal edema by aprotinin does not preserve renal perfusion and function following experimental …34169407
  • Complement factor D is linked to platelet activation in human and rodent sepsis34396466

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