Recombinant Farnesoid X Receptor (FXR) Homo sapiens (Human) Recombinant protein

NR1H4; BAR; FXR; HRR1; RIP14; Nuclear Receptor Subfamily 1,Group H,Member 4; Bile acid receptor; Farnesol receptor HRR-1; Retinoid X receptor-interacting protein 14

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Overview
Properties
  • Source Prokaryotic expression, Host E.coli
  • Endotoxin Level<1.0EU per 1µg (determined by the LAL method)
  • Subcellular LocationNucleus
  • Molecular Mass 45.9kDa, Accurate 53kDa(Analysis of differences refer to the manual)
  • Residues & TagsLeu211~Gln486 with Two N-terminal Tags, His-tag and SUMO-tag
  • Buffer FormulationPBS, pH7.4, containing 0.01% SKL, 5% Trehalose.
  • Traits Freeze-dried powder, Purity > 95%
  • Isoelectric Point5.9
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  • Recombinant Farnesoid X Receptor (FXR) Packages (Simulation)
  • Recombinant Farnesoid X Receptor (FXR) Packages (Simulation)
  • Recombinant Farnesoid X Receptor (FXR) Figure . Gene Sequencing (extract)
  • RPC042Hu01.jpg Figure. SDS-PAGE
  • Certificate ISO9001: 2008, ISO13485: 2003 Registered

Sequence

Usage

Reconstitute in 10mM PBS (pH7.4) to a concentration of 0.1-1.0 mg/mL. Do not vortex.

Storage

Avoid repeated freeze/thaw cycles. Store at 2-8°C for one month. Aliquot and store at -80°C for 12 months.

Stability

The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.

Citations

  • Raspberry pomace alters cecal microbial activity and reduces secondary bile acids in rats fed a high-fat diet.pubmed:28437712
  • Hypolipidemic effect of SIPI-7623, a derivative of an extract from oriental wormwood, through farnesoid X receptor antagonismPubmed: 30197122
  • d-Allulose enhances uptake of HDL-cholesterol into rat's primary hepatocyte via SR-B1Pubmed: 32086695

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