Recombinant Klotho (KL) Mus musculus (Mouse) Recombinant protein

KLa; Klotho Alpha

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Overview
Properties
  • Source Prokaryotic expression, Host E.coli
  • Endotoxin Level<1.0EU per 1µg (determined by the LAL method)
  • Subcellular LocationMembrane, Secreted
  • Molecular Mass 54.8kDa, Accurate 55kDa(Analysis of differences refer to the manual)
  • Residues & TagsPro516~Phe955 with N-terminal His Tag
  • Buffer FormulationPBS, pH7.4, containing 0.01% SKL, 5% Trehalose.
  • Traits Freeze-dried powder, Purity > 80%
  • Isoelectric Point6.8
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  • Recombinant Klotho (KL) Packages (Simulation)
  • Recombinant Klotho (KL) Packages (Simulation)
  • RPH757Mu01.jpg Figure. SDS-PAGE
  • Certificate ISO9001: 2008, ISO13485: 2003 Registered

Sequence

Usage

Reconstitute in 10mM PBS (pH7.4) to a concentration of 0.1-1.0 mg/mL. Do not vortex.

Storage

Avoid repeated freeze/thaw cycles. Store at 2-8°C for one month. Aliquot and store at -80°C for 12 months.

Stability

The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.

Citations

  • High phosphate feeding induced arterial medial calcification in uremic rats: Roles of Lanthanum carbonate on protecting vasculaturePubmed: 24012609
  • Sick Sinus Syndrome May Attribute to the Decrease of ?±-klotho Protein in MiceCom:Source
  • α-Klotho is an acute phase protein and altered by restraint stress in micePubmed:Pmc4203207
  • Les biomarqueurs des calcifications vasculairesPubMed: 26069069
  • Effect of secondary hyperparathyroidism serum on endothelial cells and intervention with KlothoPubMed: 25873020
  • Human Preosteoblastic Cell Culture from a Patient with Severe Tumoral Calcinosis-Hyperphosphatemia Due to a NewGALNT3PubMed: 25899975
  • 抗衰老蛋白Klotho 阻断高糖培养的大鼠肾小球系膜细胞TLR4/NF-κB p65/NGAL 通路的激活及其作用机制Cn: Article
  • The function of miR-199a-5p/Klotho regulating TLR4/NF-κB p65/NGAL pathways in rat mesangial cells cultured with high glucose and the mechanismPubMed: 26419931
  • Soluble Klotho protein as a novel serum biomarker in patients with acromegalypmc:PMC4754356
  • Klotho Deficiency Aggravates Tacrolimus-Induced Renal Injury via the Phosphatidylinositol 3-Kinase-Akt-Forkhead Box Protein O PathwayPubmed:27174564
  • Klotho preservation via histone deacetylase inhibition attenuates chronic kidney disease-associated bone injury in mice.pubmed:28387374
  • Is there a role for newer biomarkers in chronic kidney disease-mineral and bone disorder management?pubmed:28429560
  • Associations between serum fibroblast growth factor 23 level and intradialytic hypotension in hemodialysis patientsissn:2394-2916
  • Protective effect of restructuring klotho protein combined with trimetazidine on myocardial injury in miceISSN:1936-2625
  • Changes of Klotho protein and Klotho mRNA expression in a hydroxy-L-proline induced hyperoxaluric rat modelpubmed:28943597
  • Klotho Reduces Necroptosis by Targeting Oxidative Stress Involved in Renal Ischemic-Reperfusion InjuryPubmed:29550818
  • Advanced maternal age impairs spatial learning capacity in young adult mouse offspringPubmed:29636887
  • Clinical implication of alterations in serum Klotho levels in patients with type 2 diabetes mellitus and its associated complicationsPubmed:30042059
  • Klotho Inhibits Proliferation and Migration of Angiotensin II-Induced Vascular Smooth Muscle Cells (VSMCs) by Modulating NF-κB p65, Akt, and Extracellular Signal …Pubmed:30004089
  • High-serum phosphate and parathyroid hormone distinctly regulate bone loss and vascular calcification in experimental chronic kidney diseasePubmed: 30189026
  • The role of klotho in chronic kidney diseasePubmed: 30348110
  • Age-related declines in α-Klotho drive progenitor cell mitochondrial dysfunction and impaired muscle regenerationPubmed: 30451844
  • Wnt/β-catenin signaling mediates both heart and kidney injury in type 2 cardiorenal syndromePubmed: 30770217
  • The use of LP533401 as a therapeutic option for renal osteodystrophy affects, renal calcium handling, vitamin D metabolism and bone health in uremic ratsPubmed: 30801205
  • CD317 mediates immunocytolysis resistance by RICH2/cytoskeleton-dependent membrane protectionPubmed: 33223223
  • Effects of salt intervention on serum levels of Klotho influenced by salt sensitivityPubmed: 33164306
  • Expression of α-Klotho is downregulated and associated with oxidative stress in the lens in streptozotocin-induced diabetic ratsPubmed: 32744464
  • Klotho ameliorates the onset and progression of cataract via suppressing oxidative stress and inflammation in the lens in streptozotocin-induced diabetic ratsPubmed: 32438076
  • P2X7 siRNA targeted to the kidneys increases klotho and delays the progression of experimental diabetic nephropathy.Pubmed: 32377919
  • Ameliorating Effect of Klotho Protein on Rat Heart during I/R InjuryPubmed: 33123314
  • Increased Plasma Level of Longevity Protein Klotho as a Potential Indicator of Cognitive Function Preservation in Patients With SchizophreniaPubmed: 32612508
  • ¦ÁKlotho protein has therapeutic activity in contrast-induced acute kidney injury by limiting NLRP3 inflammasome-mediated pyroptosis and promoting autophagy33675964
  • Investigation of the Role of Induced Overexpression of the Isolated Secreted Klotho on the A-172 Human Glioblastoma CellsPubmed:35112226
  • Expression of Klotho in Follicles of Patients With Polycystic Ovary Syndrome and Its Clinical Significance
  • Klotho is a prognostic indicator of oocytes qualities in polycystic ovary syndrome

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