Recombinant Matrix Gla Protein (MGP) Rattus norvegicus (Rat) Recombinant protein

MGLAP; GIG36; Cell growth-inhibiting gene 36 protein

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Overview
Properties
  • Source Prokaryotic expression, Host E.coli
  • Endotoxin Level<1.0EU per 1µg (determined by the LAL method)
  • Subcellular LocationSecreted
  • Molecular Mass 16.9kDa, Accurate 19kDa(Analysis of differences refer to the manual)
  • Residues & TagsTyr20~Lys103 with N-terminal His Tag
  • Buffer Formulation20mM Tris, 150mM NaCl, pH8.0, containing 1mM EDTA, 1mM DTT, 0.01% SKL, 5% Trehalose and Proclin300.
  • Traits Freeze-dried powder, Purity > 97%
  • Isoelectric Point6.8
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  • Recombinant Matrix Gla Protein (MGP) Packages (Simulation)
  • Recombinant Matrix Gla Protein (MGP) Packages (Simulation)
  • RPB477Ra01.jpg SDS-PAGE
  • Certificate ISO9001: 2008, ISO13485: 2003 Registered

Sequence

Usage

Reconstitute in 20mM Tris, 150mM NaCl (pH8.0) to a concentration of 0.1-1.0 mg/mL. Do not vortex.

Storage

Avoid repeated freeze/thaw cycles. Store at 2-8°C for one month. Aliquot and store at -80°C for 12 months.

Stability

The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.

Citations

  • Magnesium prevents phosphate-induced calcification in human aortic vascular smooth muscle cellsPubMed: PMC3611891
  • Bone metabolism regulators and arterial stiffness in postmenopausal womenPubmed: 23916080
  • Osteoprotegerin (OPG) and Matrix Gla protein (MGP) in rheumatoid arthritis patients: Relation to disease activityScienceDirect: S1110116414000076
  • Canola and hydrogenated soybean oils accelerate ectopic bone formation induced by implantation of bone morphogenetic protein in miceResearchgate:Source
  • Markers of increased cardiovascular risk in patients with chronic kidney diseaseBiomedcentral:Source
  • The behavior of circulating matrix Gla protein, matrix metalloproteinase-9 and nitrotyrosine in patients with varicose veinsHvm:Source
  • Effect of Vitamin K2 on progression of atherosclerosis and vascular calcification in nondialyzed patients with chronic kidney disease stages 3-5PubMed: 26176325
  • Markers of increased atherosclerotic risk in patients with chronic kidney disease: a preliminary studypmc:PMC4739105
  • Plasma Desphospho-Uncarboxylated Matrix Gla Protein as a Marker of Kidney Damage and Cardiovascular Risk in Advanced Stage of Chronic Kidney DiseasePubmed:27100101
  • Matrix-Gla Protein rs4236 [A/G] gene polymorphism and serum and GCF levels of MGP in patients with subgingival dental calculuspubmed:27348051
  • Mesenchymal stromal cells-derived matrix Gla protein contribute to the alleviation of experimental colitisPubmed:29880866
  • High concentration of calcium promotes mineralization in NRK52E cells via inhibiting the expression of matrix Gla proteinPubmed:29935264
  • Serum total matrix Gla protein: Reference interval in healthy adults and variations in patients with vascular and osteoarticular diseasesPubmed: 30597137
  • Altered Mineral Metabolism and Disequilibrium Between Calcification Promoters and Inhibitors in Chronic Hemodialysis PatientsPubmed: 30847765
  • Relationship of matrix Gla protein and vitamin K with vascular calcification in hemodialysis patientsPubmed: 31538831
  • Matrix Gla protein maintains normal and malignant hematopoietic progenitor cells by interacting with bone morphogenetic protein-4Pubmed: 32322728

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