Recombinant Epiregulin (EREG) Mus musculus (Mouse) Recombinant protein

EPR; ER; Proepiregulin

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Overview
Properties
  • Source Prokaryotic expression, Host E.coli
  • Endotoxin Level<1.0EU per 1µg (determined by the LAL method)
  • Subcellular Locationn/a
  • Molecular Mass n/a, Accurate n/a(Analysis of differences refer to the manual)
  • Residues & TagsN-terminal His Tag
  • Buffer FormulationPBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
  • Traits Freeze-dried powder, Purity > 97%
  • Isoelectric Pointn/a
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  • Recombinant Epiregulin (EREG) Packages (Simulation)
  • Recombinant Epiregulin (EREG) Packages (Simulation)
  • Certificate ISO9001: 2008, ISO13485: 2003 Registered

Sequence

Usage

Reconstitute in PBS or others.

Storage

Avoid repeated freeze/thaw cycles. Store at 2-8°C for one month. Aliquot and store at -80°C for 12 months.

Stability

The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.

Citations

  • Cross-suppression of EGFR ligands amphiregulin and epiregulin and de-repression of FGFR3 signalling contribute to cetuximab resistance in wild-type KRAS tumour cellsNature: 2012103
  • Aryl hydrocarbon receptor antagonism attenuates growth factor expression, proliferation, and migration in fibroblast-like synoviocytes from patients with rheumatoid arthritis.Pubmed: 24309559
  • The Ah receptor regulates growth factor expression in head and neck squamous cell carcinoma cell linesPubmed:23625689
  • Epiregulin promotes the emergence and proliferation of adult liver progenitor cells.Pubmed:24812054
  • Epiregulin-loaded PLGA nanoparticles increase human keratinocytes proliferation: preliminary datapubmed:27383296
  • Overexpression of a functional calcium-sensing receptor dramatically increases osteolytic potential of MDA-MB-231 cells in a mouse model of bone metastasis through epiregulin-mediated osteoprotegerin downregulationPMC5593575
  • Potential Involvement of the Epidermal Growth Factor Receptor Ligand Epiregulin and Matrix Metalloproteinase-1 in Pathogenesis of Chronic Rhinosinusitispubmed:28398769
  • Epigenetic regulation of Amphiregulin and Epiregulin in colorectal cancerPubmed: 30252132
  • Epiregulin is released from intervertebral disks and induces spontaneous activity in pain pathwaysDoi: 10.1097/PR9.0000000000000718
  • Epiregulin enhances odontoblastic differentiation of dental pulp stem cells via activating MAPK signalling pathwayPubmed: 31454111
  • Promising Therapeutic Efficacy of GC1118, an Anti-EGFR Antibody, against KRAS Mutation-Driven Colorectal Cancer Patient-Derived XenograftsPubmed: 31771279
  • Patient-derived xenograft (PDX) models of colorectal carcinoma (CRC) as a platform for chemosensitivity and biomarker analysis in personalized medicinePubmed: 33212364
  • Compromised Cumulus-Oocyte Complex Matrix Organization and Expansion in Women with PCOS34748173
  • MiR-192-5p suppresses M1 macrophage polarization via epiregulin (EREG) downregulation in gouty arthritis34715618

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