Recombinant Filaggrin (FLG) Homo sapiens (Human) Recombinant protein

Profilaggrin

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Overview
Properties
  • Source Prokaryotic expression, Host E.coli
  • Endotoxin Level<1.0EU per 1µg (determined by the LAL method)
  • Subcellular LocationCytoplasm
  • Molecular Mass 55.0kDa, Accurate 70&40kDa(Analysis of differences refer to the manual)
  • Residues & TagsArg3049~Ala3361 with His and TRxA Tag
  • Buffer FormulationPBS, pH7.4, containing 0.01% SKL, 5% Trehalose.
  • Traits Freeze-dried powder, Purity > 90%
  • Isoelectric Point10.3
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  • Recombinant Filaggrin (FLG) Packages (Simulation)
  • Recombinant Filaggrin (FLG) Packages (Simulation)
  • RPJ103Hu04.jpg Figure. SDS-PAGE
  • Certificate ISO9001: 2008, ISO13485: 2003 Registered

Sequence

Usage

Reconstitute in 10mM PBS (pH7.4) to a concentration of 0.1-1.0 mg/mL. Do not vortex.

Storage

Avoid repeated freeze/thaw cycles. Store at 2-8°C for one month. Aliquot and store at -80°C for 12 months.

Stability

The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.

Citations

  • Filaggrin R501x and 2282del4 gene mutations and its tissue levels in patients with chronic plaque psoriasisLWW: 01000
  • Neuromodulatory and Anti-Inflammatory Ingredient for Sensitive Skin: In Vitro Assessment Pubmed:24931812
  • Protective Effects of Triphala on Dermal Fibroblasts and Human KeratinocytesPubmed:26731545
  • In vitro anti-inflammatory and skin protective properties of extract comprising ceramides from de-oiled rice brandoi:10.1111
  • Imiquimod-induced psoriasis-like inflammation in differentiated Human keratinocytes: Its evaluation using curcumin.pubmed:28736282
  • A novel, topical, nonsteroidal, TRPV1 antagonist, PAC-14028 cream improves skin barrier function and exerts anti-inflammatory action through modulating epidermal …Pubmed:29752146
  • In vitro anti-inflammatory and skin protective properties of Virgin coconut oil10.1016:j.jtcme.2017.06.012
  • Markers of atopic dermatitis, allergic rhinitis and bronchial asthma in pediatric patients: correlation with filaggrin, eosinophil major basic protein and …
  • Filaggrin, major basic protein and leukotriene B4: Biomarkers for adult patients of bronchial asthma, atopic dermatitis and allergic rhinitisPubmed: 30560019
  • Epidermal and Dermal Hallmarks of Photoaging are Prevented by Treatment with Night Serum Containing Melatonin, Bakuchiol, and Ascorbyl …
  • 糖化に起因する表皮機能低下に対するワイルドタイムエキスの防御効果
  • Filaggrin‐gene mutation has minimal effect on the disease severity in the lesions of atopic dermatitis34322929

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