Eukaryotic Hepcidin (Hepc) Homo sapiens (Human) Eukaryotic protein

HAMP; HFE2B; PLTR; LEAP1; Hepcidin Antimicrobial Peptide; Liver-expressed antimicrobial peptide 1; Putative liver tumor regressor

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Overview
Properties
  • Source Eukaryotic expression, Host 293F cell
  • Endotoxin Level<1.0EU per 1µg (determined by the LAL method)
  • Subcellular LocationSecreted
  • Molecular Mass 34.1kDa, Accurate 34kDa(Analysis of differences refer to the manual)
  • Residues & TagsSer25~Thr84 with N-terminal His Tag and C-terminal Fc Region of Human IgG1
  • Buffer FormulationPBS, pH7.4, containing 0.01% SKL, 5% Trehalose.
  • Traits Freeze-dried powder, Purity > 95%
  • Isoelectric Point9.4
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  • Eukaryotic Hepcidin (Hepc) Packages (Simulation)
  • Eukaryotic Hepcidin (Hepc) Packages (Simulation)
  • Eukaryotic Hepcidin (Hepc) Figure . Gene Sequencing (extract)
  • EPB979Hu61.jpg Figure. SDS-PAGE
  • Certificate ISO9001: 2008, ISO13485: 2003 Registered

Sequence

Usage

Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.

Storage

Avoid repeated freeze/thaw cycles. Store at 2-8°C for one month. Aliquot and store at -80°C for 12 months.

Stability

The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.

Citations

  • Hepcidin expression in colon during trinitrobenzene sulfonic acid-induced colitis in ratsPubmed: 24764672
  • Modulations of serum hepcidin, IL6 and iron status by different exercise regimens in ovarectomized ratsCom:Source
  • Serum iron metabolism markers including hepcidin in multiple sclerosis patientsSpringer:Source
  • Monitoring Hepcidin Level in Chronic Hepatitis C Virus Patients during TherapyZu:Source
  • Gluconeogenic signals regulate iron homeostasis via hepcidin in micePubmed:Pmc3989026
  • Inappropriate expression of hepcidin by liver congestion contributes to anemia and relative iron deficiencyPubmed:24440572
  • The action of JAK, SMAD and ERK signal pathways on hepcidin suppression by polysaccharides from Angelica sinensis in rats with iron deficiency anemiaPubmed:24752529
  • Changes in skeletal muscle iron metabolism outpace amyotrophic lateral sclerosis onset in transgenic rats bearing the G93A hmSOD1 gene mutationPubmed:25175826
  • Hepcidin and regulation of iron homeostasis in maintenance hemodialysis patientsPubmed:25193892
  • The interplay among iron metabolism, endothelium and inflammatory cascade in dysmetabolic disordersPubmed:25245337
  • An Evaluation of the Correlation between Hepcidin Serum Levels and Disease Activity in Inflammatory Bowel DiseasePubmed:25628652
  • Serum hepcidin levels in Bulgarian population.Pubmed:25651734
  • Liver Congestion in Heart Failure Contributes to Inappropriately Increased Serum Hepcidin despite AnemiaPubmed:25742771
  • Hepcidin regulation in prostate and its disruption in prostate cancerPubMed: 25858146
  • B-cell translocation gene 2 promotes hepatic hepcidin production via induction of Yin Yang 1PubMed: 25839654
  • Effect of a More Permeable Dialysis Membrane on ESA Resistance in Hemodialysis Patients - A Pilot InvestigationPubMed: 26536083
  • Urinary Hepcidin in Diagnosis of Iron Deficiency AnemiaOpenview: E01Ad7C4A9109Ed5Fadb03Ec206D7Bdc
  • Ferrous sulfate, but not iron polymaltose complex, aggravates local and systemic inflammation and oxidative stress in dextran sodium sulfate-induced colitis in ratsPubMed: 25852597
  • Iron Supplementation Attenuates the Inflammatory Status of Anemic Piglets by Regulating HepcidinPubMed: 25774043
  • Kupffer cell depletion protects against the steatosis, but not the liver damage, induced by marginal copper, high fructose diet in male rats.PubMed: 25813056
  • Hepcidin in tumor‐related iron deficiency anemia and tumor‐related anemia of chronic disease: pathogenic mechanisms and diagnosisPubMed: 24954786
  • The Effects of Treatment on Serum Hepcidin and Iron Homeostasis in HIV-1-Infected In-dividualsJournal: 59107
  • Hepcidin and iron metabolism associated with cardiometabolic risk factors in children: A case-control study.Pubmed:27139516
  • The effects of polysaccharides from the root of Angelica sinensis on tumor growth and iron metabolism in H22-bearing micePubmed:26757699
  • Hydrogen sulfide attenuates inflammatory hepcidin by reducing IL-6 secretion and promoting SIRT1-mediated STAT3 deacetylationPubmed:26154696
  • The Impact of Acute Matriptase Inhibition in Hepatic Inflammatory Models.pubmed:27642598
  • In Absence of the Cellular Prion Protein, Alterations in Copper Metabolism and Copper-Dependent Oxidase Activity Affect Iron Distribution.pubmed:27729845
  • Effects of iron supplementation in mice with hypoferremia induced by obesitypubmed:27439539
  • Hepcidin and iron metabolism associated with cardiometabolic risk factors in children: A case–control studypubmed:27139516
  • S-Propargyl-Cysteine, a Novel Hydrogen Sulfide Donor, Inhibits Inflammatory Hepcidin and Relieves Anemia of Inflammation by Inhibiting IL-6/STAT3 Pathway.pubmed:27649298
  • Hepcidin links gluco-toxicity to pancreatic beta cell dysfunction by inhibiting Pdx-1 expressionpubmed:28179377
  • Maternal and cord blood hepcidin levels based on gestational weeks in term and preterm infantspublication:305921433_Maternal_and_cord_blood_hepc
  • Acidic Polysaccharide from Angelica sinensis Reverses Anemia of Chronic Disease Involving the Suppression of Inflammatory Hepcidin and NF-κB Activationpubmed:29147463
  • Silkworm feces extract improves iron deficiency anemia via suppressing hepcidin expression and promoting iron-regulatory proteins expressionDOI: 10.1039/C7RA09576G
  • Evaluation of a competitive hepcidin ELISA assay in the differential diagnosis of iron deficiency anaemia with concurrent inflammation and anaemia of inflammation in elderly patients10.1186:s12950-017-0166-3
  • AMPK serves as a Therapeutic Target against Anemia of Inflammationpubmed:27923278
  • Micronutrient supplementation in gastric bypass surgery: prospective study on infl ammation and iron metabolism in premenopausal women10.20960/nh.1162
  • Hepcidin suppression in β‑thalassemia is associated with the down‑regulation of atonal homolog 8pubmed:28405918
  • Modulation of iron status biomarkers in tuberculosis-diabetes co-morbidity10.1016/j.tube.2017.11.011
  • The Role of Insulin Therapy in Correcting Hepcidin Levels in Patients with Type 2 Diabetes Mellitus.pubmed:28584599
  • The Effects of Angelica Sinensis Polysaccharide on Tumor Growth and Iron Metabolism by Regulating Hepcidin in Tumor-Bearing MicePubmed:29843136
  • inhibits ferroportin translation by modulating FBXL5‐IRP2 axis for its growth within host macrophagesPubmed:29470856
  • Acute and Chronic Iron Overloading Differentially Modulates the Expression of Cellular Iron-homeostatic Molecules in Normal Rat KidneyPubmed:29873589
  • Increased NGAL level associated with iron store in chronic kidney disease with anemiaPubmed:29909502
  • Relationship between obesity and iron deficiency anemia: is there a role of hepcidin?Pubmed:29318945
  • Hepcidin serum levels in HCV chronically mono-infected naïve patients, compared to healthy individuals77856
  • Effect of iron supplement from microalgae on the treatment of iron-deficient anemia in ratsDoi: 10.1039/C8FO01696H
  • New thiazolidinones reduce iron overload in mouse models of hereditary hemochromatosis and β-thalassemiaPubmed: 30792208
  • Inflammatory anemia-associated parameters are related to 28-day mortality in patients with sepsis admitted to the ICU: a preliminary observational studyPubmed: 31183575
  • Dietary gelatin enhances non-heme iron absorption possibly via regulation of systemic iron homeostasis in rats
  • 3-Amidinophenylalanine-derived matriptase inhibitors can modulate hepcidin production in vitroPubmed: 31659405
  • H2O2 induces oxidative stress damage through the BMP‐6/SMAD/hepcidin axisPubmed: 32012242
  • Increased Hepcidin Levels During a Period of High Training Load Do Not Alter Iron Status in Male Elite Junior RowersPubmed: 32038278
  • Can Calprotectin Show Subclinical Inflammation in Familial Mediterranean Fever Patients?Pubmed: 32174062
  • Iron kinetics following treatment with sucroferric oxyhydroxide or ferric citrate in healthy rats and models of anaemia, iron overload or inflammationPubmed: 32259248
  • Gold-silver core-shell nanoparticle–based impedimetric immunosensor for detection of iron homeostasis biomarker hepcidinPubmed: 33095336
  • Circulating Osteocyte‐Related Biomarkers (vitamin D, sclerostin, dickkopf-1), hepcidin, and oxidative stress markers in early breast cancer: their impact in …Pubmed: 33065276
  • Relation of serum hepcidin levels and restless legs syndrome in chronic hemodialysis patientsPubmed: 33029690
  • Difference in iron metabolism may partly explain sex-related variability in the manifestation of Wilson's diseasePubmed: 32937238
  • Expression of iron regulatory proteins in full term swine placentaPubmed: 32449967
  • Estrogen deficiency is associated with brain iron deposition via upregulation of hepcidin expression in aged female micePubmed: 32920472
  • Urinary hepcidin concentration in assessment of iron homeostasis in pediatrics
  • COMPARATIVE MONITORING OF THE ENZYME ACTIVITY OF BONE METABOLISM IN PATIENTS AFTER DENTAL IMPLANTATION
  • Serum iron, prealbumin, D-dimer and prothrombin time are indicators of the diagnosis, severity and outcome of Salmonella enterica serovar Enteritidis infection
  • Гепсидин и индекс фиброза печени MELD-XI как маркеры полиорганной недостаточности у пациентов хронической сердечной недостаточностью с …
  • Ассоциации уровней NT-proBNP и гепсидина с клинико-лабораторными параметрами у больных хронической сердечной недостаточностью с разной …
  • Correlation of hepcidin and serum ferritin levels in thalassemia patients at Chiang Mai University Hospital33565577
  • Iron metabolism is disturbed and anti-copper treatment improves but does not normalize iron metabolism in Wilson's disease33555495
  • Systemic iron deficiency does not affect the cardiac iron content and progression of heart failure34139233
  • Continuous Veno-Venous Hemofiltration (CVVH) Improves Iron Metabolism Disorders in Patients With Sepsis: A Single-Center Prospective Cohort Study
  • Evaluation of Serum Cyclooxygenase, Hepcidin Levels in Acute Renal Injury (AKI) Patients Following Cardiac Catheterization
  • High-dose ferric citrate supplementation attenuates omega-3 polyunsaturated fatty acid biosynthesis via downregulating delta 5 and 6 desaturases in rats with high-fat …34787162
  • Caffeine and alcohol-friends or foes of human iron stores?Pubmed:35063815
  • Resveratrol ameliorates iron overload induced liver fibrosis in mice by regulating iron homeostasisPubmed:35698613
  • Serum Calprotectin and Iron Metabolism Biomarker Levels in Behçet's Disease
  • Roles of homopolymeric apoferritin in alleviating alcohol-induced liver injury

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