Recombinant Procollagen I N-Terminal Propeptide (PINP)
P1NP; N-Propeptide Of Type I Procollagen; Procollagen I Amino Terminal Propeptide
- UOM
- FOB US$ 200.00 US$ 500.00 US$ 1,000.00 US$ 3,000.00 US$ 7,500.00
- Quantity
Overview
Properties
- Product No.RPA957Hu01
- Organism SpeciesHomo sapiens (Human) Same name, Different species.
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Applications
Positive Control; Immunogen; SDS-PAGE; WB.
If bio-activity of the protein is needed, please check active protein.
Research use only - DownloadInstruction Manual
- CategoryMetabolic pathwayHepatologyBone metabolism
- Source Prokaryotic expression, Host E.coli
- Endotoxin Level<1.0EU per 1µg (determined by the LAL method)
- Subcellular LocationSecreted
- Molecular Mass 27.9kDa, Accurate 40kDa(Analysis of differences refer to the manual)
- Residues & TagsGln23~Pro161 with Two N-terminal Tags, His-tag and SUMO-tag
- Buffer FormulationPBS, pH7.4, containing 0.01% SKL, 5% Trehalose.
- Traits Freeze-dried powder, Purity > 90%
- Isoelectric Point4.2
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Sequence

Usage
Reconstitute in 10mM PBS (pH7.4) to a concentration of 0.1-1.0 mg/mL. Do not vortex.
Storage
Avoid repeated freeze/thaw cycles. Store at 2-8°C for one month. Aliquot and store at -80°C for 12 months.
Stability
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
Increment services
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BCA Protein Quantification Kit
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Molecular Mass Marker for Protein
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Monoclonal Antibody Customized Service
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Polyclonal Antibody Customized Service
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Protein Activity Test Experiment Service
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Immunoprecipitation (IP) Experiment Service
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TBST Buffer
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TBS Buffer
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TRIS Buffer
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Spike RBD Protein (S-RBD)
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Protein G
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Protein A
Citations
- Is there benefit in optimising heart failure treatment in over-80 year-old patients? (HF-80 study): study protocol for a randomized controlled trial.Trials: 1745-6215
- Measurement of aminoterminal propeptide of type I procollagen (PINP) in serumScienceDirect: S0009912012001543
- Low molecular weight iron dextran increases fibroblast growth factor-23 concentration, together with parathyroid hormone decrease in hemodialyzed patientsPubMed: 22458393
- IL4 and IL-17A provide a Th2/Th17-polarized inflammatory milieu in favor of TGF-β1 to induce bronchial epithelial-mesenchymal transition (EMT)PubMed: PMC3726963
- PINP as a biological response marker during teriparatide treatment for osteoporosisPubmed: 24599274
- Zoledronic acid has differential anti-tumour activity in the pre-and post-menopausal bone microenvironment in vivoAacrjournals: Source
- Oxytocin Reverses Ovariectomy-Induced Osteopenia and Body Fat GainEndocrine: Source
- Oxytocin reverse ovariectomy-induced Osteoper and body fat gainPubmed:24506069
- The effect of topiramate and lamotrigine on rat bone mass, structure and metabolism.Pubmed:24629477
- Neurofibromin inactivation impairs osteocyte development in Nf1Prx1 and Nf1Col1 mouse modelsPubmed:24947449
- Phosphatidylethanolamine biomimetic coating increases mesenchymal stem cell osteoblastogenesisPubmed:24980874
- Effects of de-escalated bisphosphonate therapy on bone turnover biomarkers in breast cancer patients with bone metastasesPubmed:25332877
- Effect of Mirtazapine on Rat Bone Tissue after OrchidectomyPubMed: 25871861
- Oxytocin reverses osteoporosis in a sex-dependent mannerPubMed: 26042090
- Changes in Bone Metabolism Months after Laparoscopic Morbidly Obese Pre-menopausal WomenMms: Content
- Prognostic value of collagen turnover biomarkers in cardiac resynchronization therapy: A subanalysis of the TRUST CRT randomized trial populationPubmed:26776557
- Procollagen markers in microdialysate can predict patient outcome after Achilles tendon rupturecontent:2
- Bilaterale Kommunikation zwischen Osteoblasten und Osteoklastenvolltexte:2016
- Fibrosis of extracellular matrix is related to the duration of the disease but is unrelated to the dynamics of collagen metabolism in dilated cardiomyopathypubmed:27516211
- Bone turnover response is linked to both acute and established metabolic changes in ultra-marathon runnerspubmed:27422791
- Left ventricular reverse remodeling is not related to biopsy-detected extracellular matrix fibrosis and serum markers of fibrosis in dilated cardiomyopathy, regardless of the definition used for LVRRpubmed:28004175
- The effect of calcium and vitamin D supplementation on bone health of male Jockeys.pubmed:27568072
- Combined aerobic and resistance training improves bone health of female cancer survivorsS2352187216300389
- Renal Denervation Attenuates Multi-Organ Fibrosis and Improves Vascular Remodeling in Rats with Transverse Aortic Constriction Induced Cardiomyopathypubmed:27889753
- The effect of lamotrigine and phenytoin on bone turnover and bone strength: A prospective study in Wistar ratspubmed:27838501
- Sprint Interval Training Induces A Sexual Dimorphism but does not Improve Peak Bone Mass in Young and Healthy Mice.pubmed:28303909
- Low periostin levels in adult patients with Langerhans cell histiocytosis are independently associated with the disease activity.pubmed:28521873
- Erratum to: Effects on bone metabolism markers and arterial stiffness by switching to rivaroxaban from warfarin in patients with atrial fibrillationpubmed:28314975
- A Study Protocol: Spinal Morphology, Physical Performance, Quality of Life and Biochemical Markers in Adults at Risk of Osteoporotic Fractures 59f7c85aaca272607e2d8d7a
- Achilles tendon rupture healing is enhanced by intermittent pneumatic compression upregulating collagen type I synthesispubmed:28668970
- Method for the treatment of cardiovascular fibrosispatents:US9594083
- Periostin and sclerostin levels in juvenile Paget's diseasepubmed:29263750
- Congenital Hypothyroidism and Bone Remodeling Cyclepubmed:27840329
- Relationship of biomarkers of extracellular matrix with myocardial function in Type 2 diabetes mellituspubmed:28685602
- Left ventricular reverse remodeling is not related to biopsy‑detected extracellular matrix fibrosis and serum markers of fibrosis in dilated cardiomyopathy, regardless of the definition used for LVRR10.1007/s00380-016-0930-y
- Optimization of the Time Window of Interest in Ovariectomized Imprinting Control Region Mice for Antiosteoporosis Researchpubmed:29119115
- 12-month patterns of serum markers of collagen synthesis, transforming growth factor and connective tissue growth factor are similar in new-onset and chronic dilated cardiomyopathy in patients both with and without cardiac fibrosis.pubmed:28460256
- Prognostic value of fibrosis-related markers in dilated cardiomyopathy: A link between osteopontin and cardiovascular events.pubmed:29120858
- The key role of proinflammatory cytokines, matrix proteins, RANKL/OPG and Wnt/β-catenin in bone healing of hip arthroplasty patientspubmed:29129760
- TSC1 regulates osteoclast podosome organization and bone resorption through mTORC1 and Rac1/Cdc42Pubmed:29358671
- Specific Collagen Peptides Improve Bone Mineral Density and Bone Markers in Postmenopausal Women—A Randomized Controlled StudyPubmed:29337906
- Two-year cortical and trabecular bone loss in CKD-5D: biochemical and clinical predictorsPubmed:28993865
- Cholecalciferol Supplementation Promotes Bone Turnover in Chinese Adults with Vitamin D DeficiencyPubmed:29897564
- The effect of levetiracetam on rat bone mineral density, bone structure and biochemical markers of bone metabolismPubmed:29428468
- Geometric and mechanical bone response to a multidisciplinary weight loss intervention in adolescents with obesity: The ADIBOX studyPubmed:30076009
- Circulating matrix metalloproteinases and procollagen propeptides in inguinal herniaPubmed:29484522
- Effects of Amlodipine on Bone Metabolism in Orchidectomised Spontaneously Hypertensive RatsPubmed:29898457
- Coupling of bone resorption and formation by RANKL reverse signallingPubmed: 30185903
- Biomechanical and histological analyses of the fracture healing process after direct or prolonged reductionPubmed: 30180907
- Membrane-Based Microwave-Mediated Electrochemical Immunoassay for the In Vitro, Highly Sensitive Detection of Osteoporosis-Related BiomarkersPubmed: 30181433
- Structured diet and exercise guidance in pregnancy to improve health in women and their offspring: study protocol for the Be Healthy in Pregnancy (BHIP) …Pubmed: 30567604
- Effect of induction therapy with lenalidomide, doxorubicin, and dexamethasone on bone remodeling and angiogenesis in newly diagnosed multiple myelomaPubmed: 30650184
- Rapamycin improves bone mass in high-turnover osteoporosis with iron accumulation through positive effects on osteogenesis and angiogenesisPubmed: 30610968
- Quantification of N-Terminal Procollagen I Propeptide in Patients With Occlusal Trauma Induced by Prosthetic Factors
- Effect of antibiotic infused calcium sulfate/hydroxyapatite (CAS/HA) insets on implant-associated osteitis in a femur fracture model in micePubmed: 30870491
- Low fibrosis biomarker levels predict cardiac resynchronization therapy responsePubmed: 30988339
- Changes in Calciotropic Hormones and Bone Markers During Pregnancy in Response to a Nutrition+ Exercise Intervention in the Be Healthy in Pregnancy RCT (P11 …Pubmed: 31224444
- Low concentration flufenamic acid enhances osteogenic differentiation of mesenchymal stem cells and suppresses bone loss by inhibition of the NF-κB …Pubmed: 31324207
- The long noncoding RNA Crnde regulates osteoblast proliferation through the Wnt/β-catenin signaling pathway in micePubmed: 31622775
- Expression of prolactin receptors in the duodenum, kidneys and skeletal system during physiological and sulpiride-induced hyperprolactinaemiaPubmed: 30143940
- Mice lacking plastin-3 display a specific defect of cortical bone acquisitionPubmed: 31678489
- Differences in Osteoimmunological Biomarkers Predictive of Psoriatic Arthritis among a Large Italian Cohort of Psoriatic PatientsPubmed: 31717649
- BMP9 reduces bone loss in ovariectomized mice by dual regulation of bone remodelingPubmed: 31914211
- Outcome in German and South African peripartum cardiomyopathy cohorts associates with medical therapy and fibrosis markersPubmed: 32064780
- Hypoalbuminemia differently affects the serum bone turnover markers in hemodialysis patientsPubmed: 31839746
- Piezo1 Inactivation in Chondrocytes Impairs Trabecular Bone FormationPubmed: 33180356
- Extracellular matrix collagen biomarkers levels in patients with chronic thromboembolic pulmonary hypertensionPubmed: 33175289
- Development of a novel polysaccharide-based iron oxide nanoparticle to prevent iron accumulation-related osteoporosis by scavenging reactive oxygen …Pubmed: 33049237
- Mice carrying a ubiquitous R235W mutation of Wnt1 display a bone‐specific phenotypePubmed: 32369212
- FGF23 and primary hyperparathyroidism: is there a link?Pubmed: 32598019
- Qu Feng Zhi Tong capsule increases mechanical properties of cortical bone in ovariectomized rats
- 4-Hexylresorcinol Inhibits Osteoclastogenesis by Suppressing NF‐κB Signaling Pathway and Reverses Bone Loss in Ovariectomized Mice
- 淫羊藿水提物及提取药渣的抗骨质疏松药效比较研究
- Postmenapozal Tip-2 diyabetes mellitus' lu hastalarda osteoporoza bağlı kırık riskinin ve kemik Turnoveri'nin değerlendirilmesi
- Bone Turnover Markers in Osteogenesis Imperfecta and Effect of Bisphosphonate Treatment: First Egyptian Study
- A biomimetically hierarchical polyetherketoneketone scaffold for osteoporotic bone repair33310848
- Proinflammatory and bone protective role of calcitonin gene-related peptide alpha in collagen antibody-induced arthritis33221885
- Low Energy Availability with and without a High-Protein Diet Suppresses Bone Formation and Increases Bone Resorption in Men: A Randomized Controlled Pilot ¡33671093
- Lgr4 promotes aerobic glycolysis and differentiation in osteoblasts via the canonical Wnt/¦Â©\catenin pathway33950533
- Randomized, double-blind, placebo-controlled trial to examine the safety, pharmacokinetics and effects of Epimedium prenylflavonoids, on bone specific alkaline …34352588
- The Effect of Daily Methylsulfonylmethane (MSM) Consumption on High-Density Lipoprotein Cholesterol in Healthy Overweight and Obese Adults: A Randomized …34684621
- Osteoblast-specific inactivation of p53 results in locally increased bone formation34793446
- The WNT1G177C mutation specifically affects skeletal integrity in a mouse model of osteogenesis imperfecta type XV34759273
- The Effect of Caloric Restriction with and without n-3 PUFA Supplementation on Bone Turnover Markers in Blood of Subjects with Abdominal Obesity: A Randomized …34578973
- Night shift work and osteoporosis-bone turnover markers among female blue-collar workers in PolandPubmed:35139709
- Spine Metastases in Immunocompromised Mice after Intracardiac Injection of MDA-MB-231-SCP2 Breast Cancer CellsPubmed:35158823
- BMP9 reduces age-related bone loss in mice by inhibiting osteoblast senescence through Smad1-Stat1-P21 axisPubmed:35523787
- Foxf2 represses bone formation via Wnt2b/β-catenin signalingPubmed:35668101
- Osteoporotic bone recovery by a bamboo-structured bioceramic with controlled release of hydroxyapatite nanoparticlesPubmed:35386445
- Puerarin specifically disrupts osteoclast activation via blocking integrin-β3 Pyk2/Src/Cbl signaling pathwayPubmed:35228997
- Construction of a magnesium hydroxide/graphene oxide/hydroxyapatite composite coating on Mg–Ca–Zn–Ag alloy to inhibit bacterial infection and promote …Pubmed:35585377
- Exercised accelerated the production of muscle-derived kynurenic acid in skeletal muscle and alleviated the postmenopausal osteoporosis through the Gpr35 …