Recombinant Secreted Frizzled Related Protein 5 (SFRP5) Homo sapiens (Human) Recombinant protein

SARP3; Secreted Apoptosis Related Protein 3; Frizzled-related protein 1b

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Overview
Properties
  • Source Prokaryotic expression, Host E.coli
  • Endotoxin Level<1.0EU per 1µg (determined by the LAL method)
  • Subcellular LocationSecreted
  • Molecular Mass 46.4kDa, Accurate 49kDa(Analysis of differences refer to the manual)
  • Residues & TagsGlu30~His317 with Two N-terminal Tags, His-tag and SUMO-tag
  • Buffer FormulationPBS, pH7.4, containing 0.01% SKL, 5% Trehalose.
  • Traits Freeze-dried powder, Purity > 90%
  • Isoelectric Point8.7
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  • Recombinant Secreted Frizzled Related Protein 5 (SFRP5) Packages (Simulation)
  • Recombinant Secreted Frizzled Related Protein 5 (SFRP5) Packages (Simulation)
  • RPC842Hu03.jpg SDS-PAGE
  • Certificate ISO9001: 2008, ISO13485: 2003 Registered

Sequence

Usage

Reconstitute in 10mM PBS (pH7.4) to a concentration of 0.1-1.0 mg/mL. Do not vortex.

Storage

Avoid repeated freeze/thaw cycles. Store at 2-8°C for one month. Aliquot and store at -80°C for 12 months.

Stability

The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.

Citations

  • Plasma SFRP5 levels are decreased in Chinese subjects with obesity and type 2 diabetes and negatively correlated with parameters of insulin resistancePubMed: 23290274
  • Sfrp5 correlates with insulin resistance and oxidative stressPubMed: 23398169
  • Balanced duo of anti-inflammatory SFRP5 and proinflammatory WNT5A in childrenPubmed: 24603290
  • SFRP5 correlates with obesity and metabolic syndrome and increases after weight loss in childrenPubmed: 24330025
  • Circulating Sfrp5 is a signature of obesity-related metabolic disorders and is regulated by glucose and liraglutide in humansPubmed: 23185036
  • Low serum level of secreted frizzled-related protein 5, an anti-inflammatory adipokine, is associated with coronary artery diseasePubmed: 24530778
  • Identification of adipokine clusters related to parameters of fat mass, insulin sensitivity and inflammationPubmed:Pmc4072672
  • Activation of noncanonical Wnt signaling through WNT5A in visceral adipose tissue of obese subjects is related to inflammationPubmed:24840810
  • Serum secreted frizzled?related protein 5 levels differentially decrease in patients with hepatitis B virus?associated chronic infection and hepatocellular carcinomaPubmed:25120720
  • Circulating SFRP5 levels are elevated in drug‐na?ve recently diagnosed type 2 diabetic patients as compared with prediabetic subjects and controlsPubmed:25139699
  • The wingless-related integration site-5a/secreted frizzled-related protein-6 system is dysregulated in human sepsisPubmed:25382802
  • Circulating SFRP5 levels are elevated in drug-naPubMed: 25139699
  • Prediction of gestational diabetes mellitus by first trimester serum secreted frizzle-related protein-5 levelsPubMed: 26100762
  • Sfrp5 associates with beta-cell function in humansPubmed:27019073
  • Bone marrow sFRP5 level is negatively associated with bone formation markerspubmed:27986984
  • Plasma Sfrp5 levels correlate with determinants of the metabolic syndrome in Chinese adultspubmed:28303637
  • Inverse associations between serum levels of secreted frizzled-related protein-5 (SFRP5) and multiple cardiometabolic risk factors: KORA F4 studypubmed:28851362
  • Effect of SFRP5 (Secreted Frizzled–Related Protein 5) on the WNT5A (Wingless-Type Family Member 5A)-Induced Endothelial Dysfunction and Its Relevance With …Pubmed:29674475
  • Longitudinal Increases in Adiposity Contribute to Worsening Adipokine Profile over Time in Mexican AmericansPubmed:29427376
  • Decreased level of the anti-inflammatory adipokines, secreted frizzled-related protein 5 and adiponectin, in high cholesterol diet-induced atherosclerotic ratsarticle-1-352-en.pdf
  • The effect of serum and follicular fluid secreted frizzle-related protein-5 on in vitro fertilization outcomes in patients with polycystic ovary syndromePubmed: 30194556
  • Macrophage LRP1 promotes diet-induced hepatic inflammation and metabolic dysfunction by modulating Wnt signaling
  • A diet high in sugar-sweetened beverage and low in fruits and vegetables is associated with adiposity and a pro-inflammatory adipokine profilePubmed: 30375290
  • Role of wnt5a in Metabolic Inflammation in HumansPubmed: 30137542
  • Association of Adipocytokines With Carotid Intima Media Thickness and Arterial Stiffness in Obstructive Sleep Apnea PatientsPubmed: 32300333
  • Sfrp5/Wnt5a and Leptin/adiponectin levels in the serum and the periarterial adipose tissue of patients with peripheral arterial occlusive diseasePubmed: 33188773
  • Association of serum levels of secreted frizzled-related protein 5 and Wnt member 5a with glomerular filtration rate in patients with type 2 diabetes mellitus and …Pubmed: 32491086
  • Secreted Frizzled-Related Protein 5 Ameliorates Vascular Calcification in a Rat Model of Chronic Kidney Disease through the Wnt/β-Catenin Pathway34469882
  • Association of serum uromodulin with adipokines in dependence of type 2 diabetes34920231
  • Association of circulating MR-proADM with all-cause and cardiovascular mortality in the general population: Results from the KORA F4 cohort studyPubmed:34990470
  • Investigating New Sensory Methods Related to Taste Sensitivity, Preferences, and Diet of Mother-Infant Pairs and Their Relationship With Body Composition …Pubmed:35475790
  • Early Pregnancy Serum Concentration of Secreted Frizzled-Related Protein 4, Secreted Frizzled-Related Protein 5, and Chemerin in Obese Women Who Develop …

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