Recombinant Serglycin (SRGN) Rattus norvegicus (Rat) Recombinant protein

PRG; PPG; PRG1; proteoglycan 1, secretory granule

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Overview
Properties
  • Source Prokaryotic expression, Host E.coli
  • Endotoxin Level<1.0EU per 1µg (determined by the LAL method)
  • Subcellular LocationSecreted, Cytoplasm, Golgi apparatus, Extracellular matrix
  • Molecular Mass 40.2kDa, Accurate 37kDa(Analysis of differences refer to the manual)
  • Residues & TagsArg76~Ile179 with N-terminal His and GST Tag
  • Buffer FormulationPBS, pH7.4, containing 0.01% SKL, 5% Trehalose.
  • Traits Freeze-dried powder, Purity > 90%
  • Isoelectric Point3.4
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  • Recombinant Serglycin (SRGN) Packages (Simulation)
  • Recombinant Serglycin (SRGN) Packages (Simulation)
  • RPC869Ra01.jpg Figure. SDS-PAGE
  • Certificate ISO9001: 2008, ISO13485: 2003 Registered

Sequence

Usage

Reconstitute in 10mM PBS (pH7.4) to a concentration of 0.1-1.0 mg/mL. Do not vortex.

Storage

Avoid repeated freeze/thaw cycles. Store at 2-8°C for one month. Aliquot and store at -80°C for 12 months.

Stability

The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.

Citations

  • The role of increased synovial fluid A disintegrin and metalloproteinase with thrombospondin motifs4 and serglycin levels in osteoarthritisPubmed: 30536194
  • SRGN, a new identified shear-stress-responsive gene in endothelial cellsPubmed: 32712749
  • Significance of serglycin and its binding partners in autocrine promotion of metastasis in esophageal cancer33456569
  • Cancer©\associated fibroblasts secrete hypoxia©\induced serglycin to promote head and neck squamous cell carcinoma tumor cell growth in vitro and in vivo by ¡­33651283
  • Serglycin induces osteoclastogenesis and promotes tumor growth in giant cell tumor of bone34556636

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