Recombinant Retinoschisin (RS) Homo sapiens (Human) Recombinant protein

RS1; XLRS1; Retinoschisis X-Linked,Juvenile 1; X-linked juvenile retinoschisis protein

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Overview
Properties
  • Source Prokaryotic expression, Host E.coli
  • Endotoxin Level<1.0EU per 1µg (determined by the LAL method)
  • Subcellular LocationSecreted
  • Molecular Mass 53.0kDa, Accurate 53kDa(Analysis of differences refer to the manual)
  • Residues & TagsSer24~Ala224 with N-terminal His and GST Tag
  • Buffer Formulation20mM Tris, 150mM NaCl, pH8.0, containing 1mM EDTA, 1mM DTT, 0.01% SKL, 5% Trehalose and Proclin300.
  • Traits Freeze-dried powder, Purity > 95%
  • Isoelectric Point5.5
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  • Recombinant Retinoschisin (RS) Packages (Simulation)
  • Recombinant Retinoschisin (RS) Packages (Simulation)
  • RPJ847Hu01.jpg SDS-PAGE
  • Certificate ISO9001: 2008, ISO13485: 2003 Registered

Sequence

Usage

Reconstitute in 20mM Tris, 150mM NaCl (pH8.0) to a concentration of 0.1-1.0 mg/mL. Do not vortex.

Storage

Avoid repeated freeze/thaw cycles. Store at 2-8°C for one month. Aliquot and store at -80°C for 12 months.

Stability

The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.

Citations

  • Dextran and protamine-based solid lipid nanoparticles as potential vectors for the treatment of X-linked juvenile retinoschisis.PubMed: 22295905
  • Influence of Iron Oxide Nanoparticles on Innate and Genetically Modified Secretion Profiles of Mesenchymal Stem CellsScholarsportal: Source
  • A novel gene therapy vector based on hyaluronic acid and solid lipid nanoparticles for ocular diseasesPubmed:24576595
  • Structural recovery of the retina in a retinoschisin-deficient mouse after gene replacement therapy by solid lipid nanoparticlesPubmed:26986855
  • Cell based therapeutics for retinal degenerationscIRcle:1.0303136
  • An ex vivo gene therapy approach in X-linked retinoschisispubmed:27390514

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