Recombinant Serotonin Transporter (SERT) Rattus norvegicus (Rat) Recombinant protein

SLC6A4; SLC6-A4; HTT; 5-HTT; 5HTT; OCD1; hSERT; Solute Carrier Family 6,Member 4; Neurotransmitter Transporter,Serotonin; Sodium-dependent serotonin transporter

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Overview
Properties
  • Source Prokaryotic expression, Host E.coli
  • Endotoxin Level<1.0EU per 1µg (determined by the LAL method)
  • Subcellular LocationMembrane, Endosome
  • Molecular Mass 20.3kDa, Accurate 20kDa(Analysis of differences refer to the manual)
  • Residues & TagsSer483~Val630 with N-terminal His Tag
  • Buffer FormulationPBS, pH7.4, containing 0.01% SKL, 5% Trehalose.
  • Traits Freeze-dried powder, Purity > 95%
  • Isoelectric Point5.8
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  • Recombinant Serotonin Transporter (SERT) Packages (Simulation)
  • Recombinant Serotonin Transporter (SERT) Packages (Simulation)
  • RPC890Ra01.jpg Figure. SDS-PAGE
  • Certificate ISO9001: 2008, ISO13485: 2003 Registered

Sequence

Usage

Reconstitute in 10mM PBS (pH7.4) to a concentration of 0.1-1.0 mg/mL. Do not vortex.

Storage

Avoid repeated freeze/thaw cycles. Store at 2-8°C for one month. Aliquot and store at -80°C for 12 months.

Stability

The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.

Citations

  • Comparison of platelet serotonin transporter activity in subjects with severe sleep bruxism and controlPubmed:25127373
  • Experimental heart failure causes depression-like behavior together with differential regulation of inflammatory and structural genes in the brainPubmed:25400562
  • Sleep bruxism frequency and platelet serotonin transporter activities in young adult subjectsPubMed: 26527205
  • Non-Serotonergic Neurotoxicity by MDMA (Ecstasy) in Neurons Derived fromMouse P19 Embryonal Carcinoma Cells.pubmed:27861613
  • Herz-Hirn Interaktion im Mausmodell: Herzinsuffizienz nach Myokardinfarkt führt zu depressivem Verhalten bei Mäusenfrontdoor:index
  • Effects of Junk Foods on Brain Neurotransmitters (Dopamine and Serotonin) and some Biochemical Parameters in Albino Ratsarticle_1486_c0fa9f8afe5f70b407e7195bcfd55c70
  • Neuro-and nephroprotective effect of grape seed proanthocyanidin extract against carboplatin and thalidomide through modulation of inflammation, tumor …Pubmed:29854627
  • Neurotoxicity and inflammation induced by individual and combined exposure to iron oxide nanoparticles and silver nanoparticles
  • Effects of regulating gut microbiota on the serotonin metabolism in the chronic unpredictable mild stress rat modelPubmed: 31323174
  • VAMP8 and serotonin transporter levels are associated with venous thrombosis risk in a Spanish female population. Results from the RETROVE ProjectPubmed: 31382081
  • Neuronal Cell Death Induces Depressive Disorder in Rats Depression-Like Behaviors Caused by Chronic Stress
  • Administration of a Probiotic Mixture Ameliorates Cisplatin-Induced Mucositis and Pica by Regulating 5-HT in Rats34568500
  • Targeting the oxytocin system to ameliorate early life depressive-like behaviors in maternally-separated rats34349049

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