Cloud-Clone Multiplex Assay Kits For Alzheimer's Disease

Alzheimer's Disease (AD) is an insidiously onset, progressive neurodegenerative disorder. Its core pathological features include the deposition of β-amyloid (Aβ) protein in the cerebral cortex and hippocampus to form senile plaques, the abnormal phosphorylation and aggregation of tau protein to form neurofibrillary tangles, as well as massive neuronal loss and synaptic dysfunction. These changes ultimately lead to progressive cognitive decline and behavioral impairment in patients. During the pathogenesis of AD, neuroinflammatory responses and immune dysfunction play crucial roles. A variety of cytokines, chemokines, and inflammatory mediators promote disease progression through regulating microglial activation, mediating neurotoxic damage, and exacerbating impairments in amyloid protein clearance.