Monoclonal Antibody to Fibroblast Growth Factor 21 (FGF21) Homo sapiens (Human) Monoclonal antibody

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Overview
Properties
  • SourceMonoclonal antibody preparation, Host Mouse
  • Ig Isotype IgG2b Kappa, Clone Number C4
  • PurificationProtein A + Protein G affinity chromatography
  • LabelNone
  • Immunogen RPC918Hu01-Recombinant Fibroblast Growth Factor 21 (FGF21)
  • Buffer FormulationPBS, pH7.4, containing 0.02% NaN3, 50% glycerol.
  • TraitsLiquid, Concentration 1mg/ml
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  • Monoclonal Antibody to Fibroblast Growth Factor 21 (FGF21) Packages (Simulation)
  • Monoclonal Antibody to Fibroblast Growth Factor 21 (FGF21) Packages (Simulation)
  • Monoclonal Antibody to Fibroblast Growth Factor 21 (FGF21) DAB staining on IHC-P; Samples: Human Liver cancer Tissue; Primary Ab: 10µg/ml Mouse Anti-Human FGF21 Antibody Second Ab: 2µg/mL HRP-Linked Caprine Anti-Mouse IgG Polyclonal Antibody (Catalog: SAA544Mu19)
  • Monoclonal Antibody to Fibroblast Growth Factor 21 (FGF21) DAB staining on IHC-P;
    Samples: Human Stomach Tissue;
    Primary Ab: 10µg/ml Mouse Anti-Human FGF21 Antibody
    Second Ab: 2µg/mL HRP-Linked Caprine Anti-Mouse IgG Polyclonal Antibody
    (Catalog: SAA544Mu19)
  • MAC918Hu22.jpg Figure. Western Blot; Sample: Recombinant FGF21, Human.
  • Certificate ISO9001: 2008, ISO13485: 2003 Registered

Specifity

The antibody is a mouse monoclonal antibody raised against FGF21. It has been selected for its ability to recognize FGF21 in immunohistochemical staining and western blotting.

Usage

Western blotting: 0.5-2µg/mL;
Immunohistochemistry: 5-20µg/mL;
Immunocytochemistry: 5-20µg/mL;
Optimal working dilutions must be determined by end user.

Storage

Store at 4°C for frequent use. Stored at -20°C in a manual defrost freezer for two year without detectable loss of activity. Avoid repeated freeze-thaw cycles.

Stability

The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.

Giveaways

Citations

  • Dietary moderately oxidized oil induces expression of fibroblast growth factor 21 in the liver of pigsLipidworld: source
  • Orphan nuclear receptor Nur77 mediates fasting-induced hepatic fibroblast growth factor 21 expressionEndocrine:Source
  • Alpha lipoic acid induces hepatic fibroblast growth factor 21 expression via up-regulation of CREBHPubmed:25449271
  • Skeletal muscle increases FGF21 expression in mitochondrial disorders to compensate for energy metabolic insufficiency by activating the mTOR–YY1–PGC1α pathwayPubMed: 25843656
  • Associations between FGF21, osteonectin and bone turnover markers in type 2 diabetic patients with albuminuria.pubmed:27916484
  • Association of Bone Metabolic Markers With Diabetic Retinopathy and Diabetic Macular Edema in Elderly Chinese Individuals With Type 2 Diabetes Mellituspubmed:29078839
  • Ileal Transposition Surgery Decreases Fat Mass and Improves Glucose Metabolism in Diabetic GK Rats: Possible Involvement of FGF21Pubmed:29593555
  • Некоторые аспекты транспортной системы метаболизма железа в зависимости от степени синдрома перегрузки железом у детей с хроническим …
  • Fibroblast growth factor 21 (FGF21) in children and adolescents with chronic kidney disease.Pubmed: 32469231
  • 2 型糖尿病患者血清FGF21, 骨连结蛋白和骨转换指标的相关性研究.
  • Ileal transposition helps to regulate plasma hepatokine levels in obese Zucker (Crl: ZUC (ORL)-Lepr fa) rats33833309
  • The Speed of Ingestion of a Sugary Beverage Has an Effect on the Acute Metabolic Response to Fructose
  • Association of serum fibroblast growth factor 21 with kidney function in a population-based Chinese cohort34918690
  • Oxidative stress-induced growth inhibitor 1 in alcohol-induced liver cirrhosis34969228
  • Water Specific MRI T1 Mapping for Evaluating Liver Inflammation Activity Grades in Rats With Methionine‐Choline‐Deficient Diet‐Induced Nonalcoholic Fatty Liver …Pubmed:35212074
  • Fibroblast growth factor 21, a stress regulator, inhibits Drp1 activation to alleviate skeletal muscle ischemia/reperfusion injuryPubmed:35488034
  • Umbilical cord-derived mesenchymal stem cell conditioned medium reverses neuronal oxidative injury by inhibition of TRPM2 activation and the JNK signaling …Pubmed:35585377
  • High Circulating Fibroblast Growth Factor-21 Levels as a Prognostic Marker in Fatty Pancreas Patients

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