Polyclonal Antibody to Fibronectin Type III Domain Containing Protein 5 (FNDC5) Homo sapiens (Human) Polyclonal antibody

FRCP2; Irisin; Fibronectin type III repeat-containing protein 2

  • UOM
    1. 20µl
    2. 100µl
    3. 200µl
    4. 1ml
    5. 10ml
  • FOB US$ 116.00 US$ 270.00 US$ 386.00 US$ 965.00 US$ 3,860.00
  • Quantity
    Under development, coming soon!
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Overview
Properties
  • SourcePolyclonal antibody preparation, Host Rabbit
  • Ig Type IgG, Potency n/a
  • PurificationAntigen-specific affinity chromatography followed by Protein A affinity chromatography
  • LabelNone
  • Immunogen n/a
  • Buffer FormulationPBS, pH7.4, containing 0.02% NaN3, 50% glycerol.
  • TraitsLiquid, Concentration 500µg/mL
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  • Polyclonal Antibody to Fibronectin Type III Domain Containing Protein 5 (FNDC5) Packages (Simulation)
  • Polyclonal Antibody to Fibronectin Type III Domain Containing Protein 5 (FNDC5) Packages (Simulation)
  • Polyclonal Antibody to Fibronectin Type III Domain Containing Protein 5 (FNDC5) IHC Images
  • PAN576Hu01.jpg WB Image
  • Certificate ISO9001: 2008, ISO13485: 2003 Registered

Specifity

The antibody is a rabbit polyclonal antibody raised against FNDC5. It has been selected for its ability to recognize FNDC5 in immunohistochemical staining and western blotting.

Usage

Western blotting: 0.2-2µg/mL;1:250-2500
Immunohistochemistry: 5-20µg/mL;1:25-100
Immunocytochemistry: 5-20µg/mL;1:25-100
Optimal working dilutions must be determined by end user.

Storage

Store at 4°C for frequent use. Stored at -20°C in a manual defrost freezer for one year without detectable loss of activity. Avoid repeated freeze-thaw cycles.

Stability

The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.

Organism Species More: Mus musculus (Mouse), Rattus norvegicus (Rat)

Citations

  • Serum irisin levels in new-onset type 2 diabetesPubMed: 23369227
  • Lower circulating irisin is associated with type 2 diabetes mellitusPubmed: 23619195
  • Inconsistency in circulating irisin levels: what is really happeningPubmed:24459033
  • Leptin administration activates irisin-induced myogenesis via nitric oxide-dependent mechanisms, but reduces its effect on subcutaneous fat browning in micePubmed:25199621
  • Fenofibrate (PPARalpha agonist) induces beige cell formation in subcutaneous white adipose tissue from diet-induced male obese micePubmed:25576856
  • Lower irisin level in patients with type 2 diabetes mellitus: A case-control study and meta-analysisPubMed: 25494632
  • Maternal circulating levels of irisin in intrahepatic cholestasis of pregnancyPubMed: 26689349
  • Lower Circulating Irisin Level in Patients with Diabetes Mellitus: A Systematic Review and Meta-AnalysisPubmed:27300472
  • Physiology and role of irisin in glucose homeostasis.pubmed:28211512
  • Irisin improves perivascular adipose tissue dysfunction via regulation of the heme oxygenase-1/adiponectin axis in diet-induced obese micepubmed:27638193

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