Polyclonal Antibody to Hepcidin (Hepc)
HAMP; HFE2B; PLTR; LEAP1; Hepcidin Antimicrobial Peptide; Liver-expressed antimicrobial peptide 1; Putative liver tumor regressor
Overview
Properties
- Product No.PAB979Mu01
- Organism SpeciesMus musculus (Mouse) Same name, Different species.
- ApplicationsWB; IHC; ICC; IP.
If the antibody is used in flow cytometry, please check FCM antibodies.
Research use only - DownloadInstruction Manual
- CategoryMetabolic pathwayEndocrinologyHematologyGenetic science
- SourcePolyclonal antibody preparation, Host Rabbit
- Ig Type IgG, Potency n/a
- PurificationAntigen-specific affinity chromatography followed by Protein A affinity chromatography
- LabelNone
- Immunogen RPB979Mu01-Recombinant Hepcidin (Hepc)
- Buffer Formulation0.01M PBS, pH7.4, containing 0.05% Proclin-300, 50% glycerol.
- TraitsLiquid, Concentration 0.5mg/ml
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Specifity
The antibody is a rabbit polyclonal antibody raised against Hepc. It has been selected for its ability to recognize Hepc in immunohistochemical staining and western blotting.
Usage
Western blotting: 0.01-2µg/mL;
Immunohistochemistry: 5-20µg/mL;
Immunocytochemistry: 5-20µg/mL;
Optimal working dilutions must be determined by end user.
Storage
Store at 4°C for frequent use. Stored at -20°C in a manual defrost freezer for two year without detectable loss of activity. Avoid repeated freeze-thaw cycles.
Stability
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
Giveaways
Increment services
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Antibody Labeling Customized Service
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Protein A/G Purification Column
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Staining Solution for Cells and Tissue
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Positive Control for Antibody
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Tissue/Sections Customized Service
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Phosphorylated Antibody Customized Service
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Western Blot (WB) Experiment Service
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Immunohistochemistry (IHC) Experiment Service
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Immunocytochemistry (ICC) Experiment Service
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Flow Cytometry (FCM) Experiment Service
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Immunoprecipitation (IP) Experiment Service
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Immunofluorescence (IF) Experiment Service
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Buffer
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DAB Chromogen Kit
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SABC Kit
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Long-arm Biotin Labeling Kit
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Real Time PCR Experimental Service
Citations
- Hepcidin expression in colon during trinitrobenzene sulfonic acid-induced colitis in ratsPubmed: 24764672
- Modulations of serum hepcidin, IL6 and iron status by different exercise regimens in ovarectomized ratsCom:Source
- Serum iron metabolism markers including hepcidin in multiple sclerosis patientsSpringer:Source
- Monitoring Hepcidin Level in Chronic Hepatitis C Virus Patients during TherapyZu:Source
- Gluconeogenic signals regulate iron homeostasis via hepcidin in micePubmed:Pmc3989026
- Inappropriate expression of hepcidin by liver congestion contributes to anemia and relative iron deficiencyPubmed:24440572
- The action of JAK, SMAD and ERK signal pathways on hepcidin suppression by polysaccharides from Angelica sinensis in rats with iron deficiency anemiaPubmed:24752529
- Changes in skeletal muscle iron metabolism outpace amyotrophic lateral sclerosis onset in transgenic rats bearing the G93A hmSOD1 gene mutationPubmed:25175826
- Hepcidin and regulation of iron homeostasis in maintenance hemodialysis patientsPubmed:25193892
- The interplay among iron metabolism, endothelium and inflammatory cascade in dysmetabolic disordersPubmed:25245337
- An Evaluation of the Correlation between Hepcidin Serum Levels and Disease Activity in Inflammatory Bowel DiseasePubmed:25628652
- Serum hepcidin levels in Bulgarian population.Pubmed:25651734
- Liver Congestion in Heart Failure Contributes to Inappropriately Increased Serum Hepcidin despite AnemiaPubmed:25742771
- Hepcidin regulation in prostate and its disruption in prostate cancerPubMed: 25858146
- B-cell translocation gene 2 promotes hepatic hepcidin production via induction of Yin Yang 1PubMed: 25839654
- Effect of a More Permeable Dialysis Membrane on ESA Resistance in Hemodialysis Patients - A Pilot InvestigationPubMed: 26536083
- Urinary Hepcidin in Diagnosis of Iron Deficiency AnemiaOpenview: E01Ad7C4A9109Ed5Fadb03Ec206D7Bdc
- Ferrous sulfate, but not iron polymaltose complex, aggravates local and systemic inflammation and oxidative stress in dextran sodium sulfate-induced colitis in ratsPubMed: 25852597
- Iron Supplementation Attenuates the Inflammatory Status of Anemic Piglets by Regulating HepcidinPubMed: 25774043
- Kupffer cell depletion protects against the steatosis, but not the liver damage, induced by marginal copper, high fructose diet in male rats.PubMed: 25813056
- Hepcidin in tumor‐related iron deficiency anemia and tumor‐related anemia of chronic disease: pathogenic mechanisms and diagnosisPubMed: 24954786
- The Effects of Treatment on Serum Hepcidin and Iron Homeostasis in HIV-1-Infected In-dividualsJournal: 59107
- Hepcidin and iron metabolism associated with cardiometabolic risk factors in children: A case-control study.Pubmed:27139516
- The effects of polysaccharides from the root of Angelica sinensis on tumor growth and iron metabolism in H22-bearing micePubmed:26757699
- Hydrogen sulfide attenuates inflammatory hepcidin by reducing IL-6 secretion and promoting SIRT1-mediated STAT3 deacetylationPubmed:26154696
- The Impact of Acute Matriptase Inhibition in Hepatic Inflammatory Models.pubmed:27642598
- In Absence of the Cellular Prion Protein, Alterations in Copper Metabolism and Copper-Dependent Oxidase Activity Affect Iron Distribution.pubmed:27729845
- Effects of iron supplementation in mice with hypoferremia induced by obesitypubmed:27439539
- Hepcidin and iron metabolism associated with cardiometabolic risk factors in children: A case–control studypubmed:27139516
- S-Propargyl-Cysteine, a Novel Hydrogen Sulfide Donor, Inhibits Inflammatory Hepcidin and Relieves Anemia of Inflammation by Inhibiting IL-6/STAT3 Pathway.pubmed:27649298
- Hepcidin links gluco-toxicity to pancreatic beta cell dysfunction by inhibiting Pdx-1 expressionpubmed:28179377
- Maternal and cord blood hepcidin levels based on gestational weeks in term and preterm infantspublication:305921433_Maternal_and_cord_blood_hepc
- Acidic Polysaccharide from Angelica sinensis Reverses Anemia of Chronic Disease Involving the Suppression of Inflammatory Hepcidin and NF-κB Activationpubmed:29147463
- Silkworm feces extract improves iron deficiency anemia via suppressing hepcidin expression and promoting iron-regulatory proteins expressionDOI: 10.1039/C7RA09576G
- Evaluation of a competitive hepcidin ELISA assay in the differential diagnosis of iron deficiency anaemia with concurrent inflammation and anaemia of inflammation in elderly patients10.1186:s12950-017-0166-3
- AMPK serves as a Therapeutic Target against Anemia of Inflammationpubmed:27923278
- Micronutrient supplementation in gastric bypass surgery: prospective study on infl ammation and iron metabolism in premenopausal women10.20960/nh.1162
- Hepcidin suppression in β‑thalassemia is associated with the down‑regulation of atonal homolog 8pubmed:28405918
- Modulation of iron status biomarkers in tuberculosis-diabetes co-morbidity10.1016/j.tube.2017.11.011
- The Role of Insulin Therapy in Correcting Hepcidin Levels in Patients with Type 2 Diabetes Mellitus.pubmed:28584599
- The Effects of Angelica Sinensis Polysaccharide on Tumor Growth and Iron Metabolism by Regulating Hepcidin in Tumor-Bearing MicePubmed:29843136
- inhibits ferroportin translation by modulating FBXL5‐IRP2 axis for its growth within host macrophagesPubmed:29470856
- Acute and Chronic Iron Overloading Differentially Modulates the Expression of Cellular Iron-homeostatic Molecules in Normal Rat KidneyPubmed:29873589
- Increased NGAL level associated with iron store in chronic kidney disease with anemiaPubmed:29909502
- Relationship between obesity and iron deficiency anemia: is there a role of hepcidin?Pubmed:29318945
- Hepcidin serum levels in HCV chronically mono-infected naïve patients, compared to healthy individuals77856
- Effect of iron supplement from microalgae on the treatment of iron-deficient anemia in ratsDoi: 10.1039/C8FO01696H
- New thiazolidinones reduce iron overload in mouse models of hereditary hemochromatosis and β-thalassemiaPubmed: 30792208
- Inflammatory anemia-associated parameters are related to 28-day mortality in patients with sepsis admitted to the ICU: a preliminary observational studyPubmed: 31183575
- Dietary gelatin enhances non-heme iron absorption possibly via regulation of systemic iron homeostasis in rats
- 3-Amidinophenylalanine-derived matriptase inhibitors can modulate hepcidin production in vitroPubmed: 31659405
- H2O2 induces oxidative stress damage through the BMP‐6/SMAD/hepcidin axisPubmed: 32012242
- Increased Hepcidin Levels During a Period of High Training Load Do Not Alter Iron Status in Male Elite Junior RowersPubmed: 32038278
- Can Calprotectin Show Subclinical Inflammation in Familial Mediterranean Fever Patients?Pubmed: 32174062
- Iron kinetics following treatment with sucroferric oxyhydroxide or ferric citrate in healthy rats and models of anaemia, iron overload or inflammationPubmed: 32259248
- Gold-silver core-shell nanoparticle–based impedimetric immunosensor for detection of iron homeostasis biomarker hepcidinPubmed: 33095336
- Circulating Osteocyte‐Related Biomarkers (vitamin D, sclerostin, dickkopf-1), hepcidin, and oxidative stress markers in early breast cancer: their impact in …Pubmed: 33065276
- Relation of serum hepcidin levels and restless legs syndrome in chronic hemodialysis patientsPubmed: 33029690
- Difference in iron metabolism may partly explain sex-related variability in the manifestation of Wilson's diseasePubmed: 32937238
- Expression of iron regulatory proteins in full term swine placentaPubmed: 32449967
- Estrogen deficiency is associated with brain iron deposition via upregulation of hepcidin expression in aged female micePubmed: 32920472
- Urinary hepcidin concentration in assessment of iron homeostasis in pediatrics
- COMPARATIVE MONITORING OF THE ENZYME ACTIVITY OF BONE METABOLISM IN PATIENTS AFTER DENTAL IMPLANTATION
- Serum iron, prealbumin, D-dimer and prothrombin time are indicators of the diagnosis, severity and outcome of Salmonella enterica serovar Enteritidis infection
- Гепсидин и индекс фиброза печени MELD-XI как маркеры полиорганной недостаточности у пациентов хронической сердечной недостаточностью с …
- Ассоциации уровней NT-proBNP и гепсидина с клинико-лабораторными параметрами у больных хронической сердечной недостаточностью с разной …
- Correlation of hepcidin and serum ferritin levels in thalassemia patients at Chiang Mai University Hospital33565577
- Iron metabolism is disturbed and anti-copper treatment improves but does not normalize iron metabolism in Wilson's disease33555495
- Systemic iron deficiency does not affect the cardiac iron content and progression of heart failure34139233
- Continuous Veno-Venous Hemofiltration (CVVH) Improves Iron Metabolism Disorders in Patients With Sepsis: A Single-Center Prospective Cohort Study
- Evaluation of Serum Cyclooxygenase, Hepcidin Levels in Acute Renal Injury (AKI) Patients Following Cardiac Catheterization
- High-dose ferric citrate supplementation attenuates omega-3 polyunsaturated fatty acid biosynthesis via downregulating delta 5 and 6 desaturases in rats with high-fat …34787162
- Caffeine and alcohol-friends or foes of human iron stores?Pubmed:35063815
- Resveratrol ameliorates iron overload induced liver fibrosis in mice by regulating iron homeostasisPubmed:35698613
- Serum Calprotectin and Iron Metabolism Biomarker Levels in Behçet's Disease
- Roles of homopolymeric apoferritin in alleviating alcohol-induced liver injury