Monoclonal Antibody to Programmed Cell Death Protein 1 Ligand 1 (PDL1)    
    
CD274; PDCD1LG1; B7-H; B7H1; PD-L1; PDCD1L1; PDCD1-LG1; Programed Death Ligand 1
Overview
Properties
- Product No.MAA788Hu22
 - Organism SpeciesHomo sapiens (Human) Same name, Different species.
 - ApplicationsWB.
If the antibody is used in flow cytometry, please check FCM antibodies.
Research use only - DownloadInstruction Manual
 - CategorySignal transductionTumor immunityInfection immunityImmune moleculeAutoimmunity
 
- SourceMonoclonal antibody preparation, Host Mouse
 - Ig Isotype IgG1 Kappa, Clone Number C3
 - PurificationProtein A + Protein G affinity chromatography
 - LabelNone
 - Immunogen RPA788Hu01-Recombinant Programmed Cell Death Protein 1 Ligand 1 (PDL1)
 - Buffer Formulation0.01M PBS, pH7.4, containing 0.05% Proclin-300, 50% glycerol.
 - TraitsLiquid, Concentration 1mg/mL
 
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Specifity
The antibody is a mouse monoclonal antibody raised against PDL1. It has been selected for its ability to recognize PDL1 in immunohistochemical staining and western blotting.
Usage
            Western blotting: 0.01-2µg/mL;
Optimal working dilutions must be determined by end user.        
Storage
Store at 4°C for frequent use. Stored at -20°C in a manual defrost freezer for two year without detectable loss of activity. Avoid repeated freeze-thaw cycles.
Stability
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
Giveaways
Increment services
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                    Antibody Labeling Customized Service
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                    Protein A/G Purification Column
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                    Staining Solution for Cells and Tissue
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                    Positive Control  for Antibody
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                    Tissue/Sections Customized Service
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                    Phosphorylated Antibody Customized Service
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                    Western Blot (WB) Experiment Service
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                    Immunohistochemistry (IHC) Experiment Service
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                    Immunocytochemistry (ICC) Experiment Service
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                    Flow Cytometry (FCM) Experiment Service
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                    Immunoprecipitation (IP) Experiment Service
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                    Immunofluorescence (IF) Experiment Service
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                    Buffer
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                    DAB Chromogen Kit
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                    SABC Kit
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                    Long-arm Biotin Labeling Kit
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                    Real Time PCR Experimental Service
                                 
Citations
- Level of circulating PD-L1 expression in patients with advanced gastric cancer and its clinical implicationsNCBI: PMC3937742
 - High level of soluble programmed cell death ligand 1 in blood impacts overall survival in aggressive diffuse large B-Cell lymphoma: results from a French multicenter clinical trial.Pubmed:24732592
 - PD‐L1 gene polymorphisms and low serum level of PD‐L1 protein are associated to type 1 diabetes in ChilePubmed:24816853
 - Ratios of T-cell immune effectors and checkpoint molecules as prognostic biomarkers in diffuse large B-cell lymphoma: a population-based studyPubMed: 26686046
 - High levels of the soluble programmed death-ligand (sPD-L1) identify hepatocellular carcinoma patients with a poor prognosis.Pubmed:27039170
 - Serum levels of soluble programmed cell death ligand 1 as a prognostic factor on the first-line treatment of metastatic or recurrent gastric cancerarticle:10.1007
 - PD-L1 is upregulated by EBV-driven LMP1 through NF-κB pathway and correlates with poor prognosis in natural killer/T-cell lymphomapubmed:27737703
 - High plasma levels of soluble programmed cell death ligand 1 are prognostic for reduced survival in advanced lung cancer.pubmed:28212990
 - Soluble programmed death-ligand 1 (sPDL1) and neutrophil-to-lymphocyte ratio (NLR) predictssurvival in advanced biliary tract cancer patients treated with palliative chemotherapy.pubmed:27780932
 - High post-treatment serum levels of soluble programmed cell death ligand 1 predict earlyrelapse and poor prognosis in extranodal NK/T cell lymphoma patients.pubmed:27105512
 - Soluble PD-L1: A biomarker to predict progression of autologous transplantation in patients with multiple myelomapubmed:27566569
 - Programmed death-ligand 1 and its soluble form are highly expressed in nasal natural killer/T-cell lymphoma: a potential rationale for immunotherapy.pubmed:28349165
 - Soluble programmed death-ligand 1 as a prognostic biomarker for overall survival in patients with diffuse large B-cell lymphoma: a replication study and combined analysis of 508 patientsleu2016385a
 - Plasma levels of soluble programmed death ligand-1 may be associated with overall survival in nonsmall cell lung cancer patients receiving thoracic radiotherapy.pubmed:28207525
 - Inverse correlation of soluble programmed cell death-1 ligand-1 (sPD-L1) with eosinophil count and clinical severity in allergic rhinitis patientspubmed:27617656
 - Plasma levels of soluble programmed death ligand-1 may be associated with overall survival in nonsmall cell lung cancer patients receiving thoracic radiotherapyPMC5319514
 - Soluble Programed Death Receptor 1 Ligand (sPD-L1) in Pleural Fluid of Patients with Malignant Pleural Mesothelioma (MPM)Pdf:10.1164
 - Soluble Programmed Cell Death Ligand 1 as a Novel Biomarker for Nivolumab Therapy for Non–Small-cell Lung CancerPubmed:29859759
 - Increased levels of soluble programmed death ligand 1 associate with malignancy in patients with dermatomyositisPubmed:29419471
 - High Serum Level of Soluble Programmed Death Ligand 1 is Associated With a Poor Prognosis in Hodgkin LymphomaPubmed:29698935
 - Increased levels of soluble co-stimulatory molecule PD-L1 (B7-H1) in the plasma of viraemic HIV-1+ individualsPubmed: 30236481
 - Pre-treatment serum levels of soluble programmed cell death-ligand 1 predict prognosis in patients with hepatitis B-related hepatocellular carcinomaPubmed: 30267213
 - Soluble PD-L1 Expression in Circulation as a Predictive Marker for Recurrence and Prognosis in Gastric Cancer: Direct Comparison of the Clinical Burden Between …Pubmed: 30565045
 - Identification of programmed cell death 1 and its ligand in the testicular tissue of micePubmed: 30578744
 - Clinical significance of soluble programmed cell death-1 and soluble programmed cell death-ligand 1 in patients with locally advanced rectal cancer treated …Pubmed: 30807610
 - Elevated levels of soluble PD-L1 are associated with reduced recurrence in papillary thyroid cancerPubmed: 31252406
 - Prognostic implications of soluble programmed death-ligand 1 and its dynamics during chemotherapy in unresectable pancreatic cancerPubmed: 31366979
 - The Clinical Significance of Soluble PD-1 and PD-L1 in Lung CancerPubmed: 31675543
 - Clinical implications of APOBEC3A and 3B expression in patients with breast cancerPubmed: 32176735
 - Predictive Value of Soluble PD-1, PD-L1, VEGFA, CD40 Ligand and CD44 for Nivolumab Therapy in Advanced Non-Small Cell Lung Cancer: A Case-Control StudyPubmed: 32085544
 - Serum levels of soluble programmed death-ligand 1 (sPD-L1) in patients with primary central nervous system diffuse large B-cell lymphomaPubmed: 32054467
 - The prognostic role of soluble transforming growth factor‐β and its correlation with soluble programmed death‐ligand 1 in biliary tract cancerPubmed: 32780918
 - Prognostic impacts of tumoral expression and serum levels of PD-L1 and CTLA-4 in colorectal cancer patientsPubmed: 32577816
 - Soluble PD-L1: a potential immune marker for HIV-1 infection and virological failurePubmed: 32443313
 - The clinical implication of soluble PD-L1 (sPD-L1) in patients with breast cancer and its biological function in regulating the function of T lymphocyte33688997
 - Prognostic prospect of soluble programmed cell death ligand-1 (sPD-L1) in cancer management34180502
 - Microglial PD‐1 stimulation by astrocytic PD‐L1 suppresses neuroinflammation and Alzheimer's disease pathology34825707
 - A Novel Small Cyclic Peptide-Based 68Ga-Radiotracer for Positron Emission Tomography Imaging of PD-L1 Expression in Tumors34910492
 - Macrophage Associated Immune Checkpoint CD47 Blocking Ameliorates EndometriosisPubmed:35404426
 - Microbial hydrogen “manufactory” for enhanced gas therapy and self-activated immunotherapy via reduced immune escapePubmed:35705974
 - Assessment of the RANTES Level Correlation and Selected Inflammatory and Pro-Angiogenic Molecules Evaluation of Their Influence on CRC Clinical Features: A …Pubmed:35208526
 
