Polyclonal Antibody to Neuregulin 1 (NRG1) Rattus norvegicus (Rat) Polyclonal antibody

ARIA; GGF; HGL; HRG; HRGA; NDF; SMDF; Acetylcholine receptor-inducing activity; Glial growth factor; Heregulin; Neu differentiation factor; Sensory and motor neuron-derived factor

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Overview
Properties
  • SourcePolyclonal antibody preparation, Host Rabbit
  • Ig Type IgG, Potency n/a
  • PurificationAntigen-specific affinity chromatography followed by Protein A affinity chromatography
  • LabelNone
  • Immunogen RPB866Ra04-Recombinant Neuregulin 1 (NRG1)
  • Buffer Formulation0.01M PBS, pH7.4, containing 0.05% Proclin-300, 50% glycerol.
  • TraitsLiquid, Concentration 0.69mg/ml
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  • Polyclonal Antibody to Neuregulin 1 (NRG1) Packages (Simulation)
  • Polyclonal Antibody to Neuregulin 1 (NRG1) Packages (Simulation)
  • Polyclonal Antibody to Neuregulin 1 (NRG1) DAB staining on IHC-P; Samples: Rat Cerebrum Tissue; Primary Ab: 20µg/ml Rabbit Anti-Rat NRG1 Antibody Second Ab: 2µg/mL HRP-Linked Caprine Anti-Rabbit IgG Polyclonal Antibody (Catalog: SAA544Rb19)
  • Polyclonal Antibody to Neuregulin 1 (NRG1) DAB staining on IHC-P;
    Sample: Rat Cerebrum Tissue
    Primary Ab: 20µg/ml Rabbit Anti-Rat NRG1 Antibody
    Control: Used PBS instead of primary antibody
    Second Ab: 2µg/ml HRP-Linked Caprine Anti-Rabbit IgG Polyclonal Antibody
    (Catalog: SAA544Rb19)
  • PAB866Ra04.jpg Western Blot; Samples: Lane1: SH-SY5Y cell lysate; Lane2: HUH7 cell lysate; Primary Ab: 0.2µg/ml Rabbit Anti-Rat NRG1 Antibody Second Ab: 0.2µg/ml HRP-Linked Caprine Anti-Rabbit IgG Polyclonal Antibody (Catalog: SAA544Rb19)
  • Polyclonal Antibody to Neuregulin 1 (NRG1) Western Blot; Sample: Lane1: Rat Serum; Lane2: 293T cell lysate
    Primary Ab: 1μg/ml Rabbit Anti-Rat NRG1 Antibody
    Second Ab: 0.2µg/mL HRP-Linked Caprine Anti-Rabbit IgG Polyclonal Antibody
    (Catalog: SAA544Rb19)
  • Certificate ISO9001: 2008, ISO13485: 2003 Registered

Specifity

The antibody is a rabbit polyclonal antibody raised against NRG1. It has been selected for its ability to recognize NRG1 in immunohistochemical staining and western blotting.

Usage

Western blotting: 0.5-2µg/mL;
Immunohistochemistry: 5-20µg/mL;
Immunocytochemistry: 5-20µg/mL;
Optimal working dilutions must be determined by end user.

Storage

Store at 4°C for frequent use. Stored at -20°C in a manual defrost freezer for two year without detectable loss of activity. Avoid repeated freeze-thaw cycles.

Stability

The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.

Organism Species More: Homo sapiens (Human)

Giveaways

Citations

  • Therapeutic effect of co-transplantation of neuregulin 1-transfected-Schwann cells and bone marrow stromal cells on spinal cord hemisection syndromCyagen: source
  • ADAM17 Silencing in Mouse Colon Carcinoma Cells: The Effect on Tumoricidal Cytokines and AngiogenesisPubMed: PMC3519469
  • Cerebrospinal fluid–based kinetic biomarkers of axonal transport in monitoring neurodegenerationPubMed: PMC3428100
  • Dysregulation of Neuregulin-1/ErbB signaling in the prefrontal cortex and hippocampus of rats exposed to chronic unpredictable mild stressPubMed: 26626816
  • Effects of prolonged antipsychotic administration on neureCavia (Guinea pig )lin-1/ErbB signaling in rat prefrontal cortex and myocardium: implications for the therapeutic action and cardiac adverse effect.Pubmed:26961615
  • Qiliqiangxin protects against anoxic injury in cardiac microvascular endothelial cells via NRG-1/ErbB-PI3K/Akt/mTOR pathway.pubmed:28271613
  • Ablation of neuropsin-neuregulin 1 signaling imbalances ErbB4 inhibitory networks and disrupts hippocampal gamma oscillation.pubmed:28267150
  • A proteasome-resistant fragment of NIK mediates oncogenic NF-κB signaling in schwannomasPubmed: 30335132
  • Jinmaitong ameliorates diabetic peripheral neuropathy in streptozotocin-induced diabetic rats by modulating gut microbiota and neuregulinPubmed: 32920546

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