On August 6, 2022,ZhengGuo, Department of Orthopaedics, Tangdu Hospital, Fourth Military Medical University, PR China, and his team published a paper titled “Dynamic degradation patterns of porous polycaprolactone/β-tricalcium phosphate composites orchestrate macrophage responses and immunoregulatory bone regeneration” in Bioactive Materials. They established a steady in vitro degradation model to investigate the changes in the physio-chemical and biological properties of PT scaffolds during degradation.The kits [ELISA Kit for Interleukin 10 (IL10), SEA056Mu] of Cloud-Clone brand was chosed in this article, we are so proud for supporting the reaserchers.Biodegradable polycaprolactone/β......

Cardiomyopathy is a relatively rare and refractory myocardial disease caused by genetic and environmental factors.Cardiomyopathy is classified into dilated cardiomyopathy, hypertrophic cardiomyopathy, arrhythmogenic right ventricular cardiomyopathy, restrictive cardiomyopathy, and unclassified cardiomyopathy. Major risk factors includes family history of cardiomyopathy, coronary heart disease, obesity, long term high blood pressure, alcoholism, chronic kidney disease and diabetes. Clarification of the genotype–phenotype correlation is needed to develop the precision medicine in cardiomyopathy. In addition, elucidation of the mechanisms involved in cardiomyopathy onset and progression f......

On August 6, 2022, Guosheng Cheng, School of Nano-Tech and Nano-Bionics, University of Science and Technology of China, China, and his team published a paper titled “Specific anti-glioma targeted-delivery strategy of engineered small extracellular vesicles dual-functionalised by Angiopep-2 and TAT peptides” in Journal of Extracellular Vesicles. They showed that utilization of the dualmodified small extracellular vesicles (sEVs) represents a unique and efficient strategy for drug delivery, holding great promise for the treatments of central nervous system diseases.The kits [ELISA Kit for Creatine Kinase MB Isoenzyme (CKMB), SEA479Mu; ELISA Kit for Aspartate Aminotransferase (AST), SEB21......

Ferroptosis, a regulated program of cell death, results from the mis-controlled accumulation of membrane lipid peroxidation in an iron-dependent manner, which is distinguished from other programmed cell deaths such as apoptosis, necrosis or pyroptosis. Factors including the depletion of glutathione (GSH), and the inhibition of cystine/glutamate antiporter system or glutathione peroxidase 4 (GPX4) can trigger ferroptosis. On the other hand, ferroptosis can be inhibited by iron chelators (e.g., deferoxamine), and lipophilic anti-oxidants (e.g., N-acetyl-L-cysteine, ferrostatin-1, and vitamin E). Notably, ferroptosis is closely related to the development and control of various liver disea......

On July 14, 2022,Wei Liu, Department of Plastic and Reconstructive Surgery, Shanghai Key Laboratory of Tissue Engineering, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, China, and his team published a paper titled “Step-wise CAG@PLys@PDA-Cu2+modification on micropatterned nanofibers for programmed endothelial healing” in Bioactive Materials. Their study showed that step-wise modification of CAG@PLys@PDA-Cu2+on micropatterned nanofibers can significantly promote endothelial healing without inflicting thrombosis, thus confirming a novel strategy for developing functional vascular grafts or other bloodcontacting materials/devices.The antibodies[Mo......

Atopic dermatitis (AD) is a recurrent, chronic, non-infectious inflammatory dermatosis characterized by persistent itching of the skin. Theclinical picture includes eczema-like eruptions, such as erythema, papules, exudative lesions of a specific location, depending on the patient’s age andvarious skin degrees of dryness. The pathophysiology of atopic dermatitis is complex and multifactorial.Its understanding is complicated by the number of synergized factors that influence the disease. The most important are: genetic disorders, a defect in the epidermal barrier, an altered immune response and disturbed microbiological balance of the skin. In addition, environmental factors such as inc......